From blood to brain: blood cell-based biomimetic drug delivery systems |
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| Authors: | Yong-Jiang Li Jun-Yong Wu Jihua Liu Xiaohan Qiu Wenjie Xu Tiantian Tang Da-Xiong Xiang |
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| Affiliation: | aDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China;bHunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug, Changsha, China;cInstitute of Clinical Pharmacy, Central South University, Changsha, China |
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| Abstract: | Brain drug delivery remains a major difficulty for several challenges including the blood–brain barrier, lesion spot targeting, and stability during circulation. Blood cells including erythrocytes, platelets, and various subpopulations of leukocytes have distinct features such as long-circulation, natural targeting, and chemotaxis. The development of biomimetic drug delivery systems based on blood cells for brain drug delivery is growing fast by using living cells, membrane coating nanotechnology, or cell membrane-derived nanovesicles. Blood cell-based vehicles are superior delivery systems for their engineering feasibility and versatile delivery ability of chemicals, proteins, and all kinds of nanoparticles. Here, we focus on advances of blood cell-based biomimetic carriers for from blood to brain drug delivery and discuss their translational challenges in the future. |
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| Keywords: | Blood brain barrier blood cells biomimetic brain drug delivery |
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