盘状蛋白结构域受体与肿瘤免疫的研究进展

研究发现盘状蛋白结构域受体表达异常与肿瘤发生及进展密切相关，参与肿瘤细胞黏附、迁移、增殖和基质重塑，且在肿瘤免疫反应过程中发挥重要作用。部分小分子盘状蛋白结构域受体抑制剂在多种实体瘤中已显示出初步临床疗效。全文就盘状蛋白结构域受体与肿瘤免疫相关方面的研究进行综述，阐述盘状蛋白结构域受体与肿瘤免疫微环境的相互作用，及其作为抗癌新靶点联合抗肿瘤治疗的相关临床研究的进展，展望多种实体瘤靶向盘状蛋白结构域受体的精准治疗前景和挑战。

Advances on Discoidin Domain Receptors and Tumor Immunity

Abstract： The abnormal expression of discoidin domain receptors (DDRs) has been revealed in tumor tissues， which is involved in tumor cell adhesion， migration， proliferation and stromal remodeling， and plays an important role in tumor immune response. Recently， some small-molecule inhibitors of DDRs have shown preliminary clinical efficacy in a variety of solid tumors. This paper reviews the research advances on the DDRs and tumor immunity， focusing on the interactions between DDRs and the tumor immune microenvironment， and the application of DDRs as a new target for anti-tumor therapy， and also discusses the prospects and challenges of the DDRs-targeted immunotherapy for a wide range of solid tumors.