慢性阻塞性肺疾病患者血清中细胞间粘附分子-1、E-选择素含量变化及意义

目的：研究细胞间粘附分子-1（ICAM-1）及E-选择素与慢性阻塞性肺疾病（COPD）发病的关系。方法：采用酶联免疫吸附试验（ELISA）方法检测30例DOPD急性加重期、缓解期的患者和20例正常对照者血清中的ICAM-1、E-选择素的水平，并将其与患者动脉血气中PO2、PCO2、肺功能FEV1%进行比较。结果：COPD患者中ICAM-1、E-选择素的水平明显高于正常对照组（P＜0.01)，且急性加重期明显高于缓解期（P＜0.001)，对19例急性加重期患者治疗前后对比分析具有显著差异（P＜0.001)。同时发现ICAM-1、E-选择素与PCO2呈正相关，与PO2及FEV1%呈负相关。结论：ICAM-1、E-选择素参与了COPD的发病，检测血清中的ICAM-1、E-选择素水平对判断COPD的病情轻重程度、治疗效果及预后具有重要的临床意义。

Clinical significance of serum ICAM-1 and E-selectin in patients with chronic obstructive pulmonary disease

Objective To study the role of ICAM 1 and E selectin in chronic obstructive pulmonary disease(COPD).Methods Double antibody sandwich quantitative enzyme lined immunosorbent assay(ELISA) method was used to measure the serum levels of E selectin and ICAM 1 in 30 patients with chronic obstructive pulmonary disease and 20 normal control subjects,PO 2,PCO 2 and FEV 1% were compared also.Results The ICAM 1 and E selectin levels in patients with COPD were significantly higher than that in control subjects( P <0.01).There were also significant differences in serum ICAM 1,E selectin levels of patients between acute stage and remissive stage,pre and post treatment( P <0.001),at the same time,serum ICAM 1 and E selectin levels had positive correlation with PCO 2,and negative correlation with PO 2 and FEV%.Conclusion ICAM 1 and E selectin participates in happeness of COPD.Serum ICAM 1 and E selectin levels has important significance in judging illness situation of COPD and therapeutic efficacy and prognosis.