短期胰岛素强化治疗对初诊2型糖尿病患者机体炎症状态的影响

目的:观察短期胰岛素强化治疗对伴显著高血糖的初诊2型糖尿病患者机体炎症状态的影响。方法:对21例空腹血糖>11.1mmol/L的初诊2型糖尿病患者进行短期胰岛素强化治疗,比较治疗前及治疗2周后肿瘤坏死因子α(TNF-α)、CRP的变化及其与糖负荷后30min胰岛素增值与血糖增值的比值(△I30'/△G30')、HomaB功能指数和Homa-IR的关系。结果:治疗2周,血清TNF-α和CRP水平明显下降(P<0.01),△I30'/△G30'增高(P<0.05),HomaB功能指数明显上升(P<0.01),Homa-IR下降(P<0.01);血TNF-α和CRP水平与HomaB功能指数和Homa-IR有相关关系(P<0.05)。结论:对显著高血糖初诊2型糖尿病患者进行短期胰岛素强化治疗可快速控制血糖,减轻机体的炎症反应。

Short-term insulin intensive therapy for inflammation in newly-diagnosed type 2 diabetics

Objective：To observe the effect of short-term insulin intensive therapy on the inflammation in newly-diagnosed type 2 diabetics. Methods ：Twenty-one newly-diagnosed type 2 diabetic patients with fasting blood sugar（FBG） 〉 11.1 mmol/L were treated by short-term insulin intensive therapy for 2 weeks. The fasting serum tumor necrosis factor-α（TNF-α） and CRP were compared before and after the therapy,and their relationship with △I30＇/△G30＇, Homa-B function index and Homa-IR were observed. Results：After 2 weeks of treatment, the CRP, TNF-α and Hama-IR decreased significantly （ P 〈 0.01 ）, and △I30＇/△G30＇ increased significantly （ P 〈 0.05）; Homa B was obviously increased （P 〈0.01 ）;serum CRP and TNF-et was greatly related with Homa B function index and Hama-IR （ P 〈 0.05 ）. Conclusions： Short-term intensive therapy may control the markedly increased blood glucose in newly-diagnosed type 2 diabetic patients and alleviate their inflammation reaction.