| 泰山四叶参精制多糖对小鼠耐缺氧及抗疲劳能力的影响 |
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| 引用本文： | 赵燕燕,苏美英,王莉,谷红霞,周茂金.泰山四叶参精制多糖对小鼠耐缺氧及抗疲劳能力的影响[J].中国医院药学杂志,2011(8). |
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| 作者姓名： | 赵燕燕 苏美英 王莉 谷红霞 周茂金 |
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| 作者单位： | 烟台大学药学院;山东省泰安市中心医院; |
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| 基金项目： | 泰安市中药现代化科技攻关项目 |
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| 摘 要： | 目的:观察通过D101大孔树脂精制的4年生泰山四叶参多糖对小鼠耐缺氧和抗疲劳能力的影响。方法:用水提醇沉法和大孔树脂对四叶参多糖进行提取和纯化,得到精制的四叶参多糖。昆明种小鼠,按照性别和体质量随机分4组(n=10),分别为对照组,高、中、低3个剂量组,灌胃10d后,采用耐缺氧和负重游泳的实验方法,测定小鼠不同时间的累计耗氧量,缺氧存活时间和负重游泳存活时间。结果:高剂量组可明显降低小鼠累计耗氧量,延长小鼠缺氧存活时间和负重游泳存活时间。结论:4年生泰山四叶参大孔树脂精制多糖具有明显的提高小鼠耐缺氧及抗疲劳能力的作用。
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| 关 键 词： | 四叶参多糖 抗疲劳 耐缺氧 小鼠 |
Effects of anti-fatigue and hypoxia tolerance of purified polysaccharide of Radix Codonopsitis Lanceolatae in mice |
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| ZHAO Yan-yan,SU Mei-ying,WANG Li,GU Hong-xia,ZHOU Mao-jin.Effects of anti-fatigue and hypoxia tolerance of purified polysaccharide of Radix Codonopsitis Lanceolatae in mice[J].Chinese Journal of Hospital Pharmacy,2011(8). |
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| Authors: | ZHAO Yan-yan SU Mei-ying WANG Li GU Hong-xia ZHOU Mao-jin |
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| Institution: | ZHAO Yan-yan1,SU Mei-ying2,WANG Li2,GU Hong-xia2,ZHOU Mao-jin2(1.Pharmacy School of Yantai University,Shandong Yantai 264003,China,2.Taian Central Hospital of Shandong Province,Shandong Taian 271000,China) |
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| Abstract: | OBJECTIVE To study the effects of anti-fatigue function and hypoxia tolerance of purified polysaccharide of 4 year Radix Codonopsitis lanceolatae in mice.METHODS The purified polysaccharides were extracted from plant meals of 4 year Radix Codonopsi lanceolatae with water and alcohol.Kunming mice were divided into the control and experiment group at random according to weight.The experiment group was subdivided into high,moderate and low dosage group.Mice were fed with physiological saline and polysaccharide... |
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| Keywords: | Codonopsitis lanceolatae polysaccharide hypoxia tolerance anti-fatigue mice |
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