Effect of laparoscopic ovarian drilling on vascular endothelial growth factor and ovarian stromal blood flow using 3-dimensional power Doppler |
| |
Authors: | Manal M El Behery Abdalla E Diab Moustafa A Ebrahiem |
| |
Institution: | a Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egyptb Department of Biochemistry, Faculty of Medicine, Zagazig University, Egypt |
| |
Abstract: | ObjectiveTo determine, by using 3-dimensional power Doppler ultrasonography, the effect of laparoscopic ovarian drilling (LOD) on the serum level of vascular endothelial growth factor (VEGF) and ovarian stromal blood flow changes in polycystic ovary syndrome (PCOS).MethodsA prospective controlled clinical study was conducted on 26 clomiphene-resistant women with PCOS who were scheduled for LOD and a control group of 22 fertile regularly menstruating women. VEGF and 3 ovarian Doppler indices—vascularization index, flow index, and vascularization flow index—were measured and compared between the 2 groups, and before and after LOD in the PCOS group.ResultsSerum VEGF and the Doppler indices of ovarian stromal blood flow were significantly higher in the PCOS group than in the control group. Serum VEGF and the ovarian stromal blood flow Doppler indices were significantly reduced in the PCOS group after LOD.ConclusionIncreased vascularity in PCOS demonstrated by Doppler blood flow measurements might be explained by the high level of VEGF. LOD reduced ovarian vascularization and serum VEGF. |
| |
Keywords: | 3D power Doppler Laparoscopic ovarian drilling Polycystic ovary syndrome Vascular endothelial growth factor |
本文献已被 ScienceDirect 等数据库收录! |
|