电化学治疗联合肝动脉、门静脉双管灌注化疗治疗中晚期肝癌

目的探讨电化学治疗联合肝动脉、门静脉双管灌注化疗治疗中晚期肝癌临床疗效。方法 96例经病理证实无法手术的中晚期肝癌患者,分为两组;A组(N=58例)经肝动脉和门静脉插管灌注化疗皮下埋植化疗泵组,B组(N=30例)电化学治疗联合肝动脉、门静脉双管灌注化疗组。结果 A、B两组的总有效率分别为13.7％和42.1％;治疗后获得二期手术切除术率分别为0和10.5％(P<0.05);生存率0.5、1、2年分别为58.9％、46.5％、12.1％和86.9％、65.9％、40.2％(P<0.05);并发症差异无显著意义。结论电化学治疗联合肝动脉、门静脉双管灌注化疗是治疗中晚期肝癌的有效方法。

Electrochemical Therapy in Combination with Therapy Hepatic Artey and Portal Vein Dual Perfusion Chemotherapy in Treatment of Advanced Primary he Patocellular Cancer

Objective To investigate the therapeutic effects of electrochemical therapy in combination with hepatic artery and portal vein dual perfusion chemotherapy in treatment of advanced primary hepatocellular cancer. Methods A total of 99 patients with pathologically proven and unrespectable primary hepatocellular cancer were divided into two groups.In group A (n= 58), the patients were treated with hepatic artery and portal vein dual perfusion chemotherapy through a hypodermic implanted drug delivery pump.In group B (n = 38), the patients were treated with electrochemical herapy tin combination with hepatic artery and portal vein dual perfusion chemotherapy. Results The total effective rate was 13.7% and 42.1 in group A and group B, respectively.There was a significant difference between the two groups (P<0.05) .The secondary respectable rate was 0 and 10.5% in group A and group B, respectively (P< 0.05) .The half- , 1 - and 2 year survival rates were 59.8%, 46.5% and 12.1% in group A but 86.9%, 65.9% and 40.2% in group B, respectively.There were significant differences between the two groups (P < 0.05) .However, there was no marked difference in incidence rate of complications between the two groups (P < 0.05) . Conclusions The therapeutic effect of electrochemical therapy in combination chemo therapy in advanced, primary hepatocelluar cancer is better than that of hepatic artery and portal dual perfusion chemotheratpy alone.