| 基于EB病毒的肿瘤靶向治疗策略 |
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| 引用本文： | 景钊,张薛榜,吴式琇. 基于EB病毒的肿瘤靶向治疗策略[J]. 国外医学(肿瘤学分册), 2007, 0(7) |
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| 作者姓名： | 景钊 张薛榜 吴式琇 |
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| 作者单位： | 温州医学院附属第一医院放疗科，温州医学院附属第一医院放疗科，温州医学院附属第一医院放疗科 |
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| 基金项目： | 国家自然科学基金(30670621) |
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| 摘 要： | 爱泼斯坦-巴尔病毒(EBV)相关肿瘤中存在EBV及其产物,为特异性杀伤肿瘤细胞提供了理想靶点。通过抑制EBV转化蛋白表达,靶向EBV复制启动元件,诱导EBV裂解感染以及EBV特异性免疫治疗等途径,为肿瘤治疗提供了新的以病毒为靶点的治疗策略。
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| 关 键 词： | 疱疹病毒4型，人 免疫疗法 肿瘤 |
Virally targeted therapies for EBV-associated neoplasms |
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| JING Zhao ZHANG Xue-bang WU Shi-xiu. Virally targeted therapies for EBV-associated neoplasms[J]. Foreign Medical Sciences (Cancer Section), 2007, 0(7) |
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| Authors: | JING Zhao ZHANG Xue-bang WU Shi-xiu |
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| Affiliation: | JING Zhao ZHANG Xue-bang WU Shi-xiu Department of Radiation Oncology,the First Affiliated Hospital of Wenzhou Medical College.Wenzhou 325000,China |
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| Abstract: | The presence of the EBV genome within related tumors presents us with ideal target for cancer treatments.EBV-targeted strategies for treating cancer include inhibiting EBV transforming proteins, targeting Orip replication complexes,induction of the lyric form of EBV infection,and EBV specific immuno- therapy.In this article,we will review a variety of different virally targeted therapies for EBV-associated neo- plasms. |
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| Keywords: | Herpesvirus 4 human Immunotherapy Neoplasms |
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