山东省海阳市社区居民高尿酸血症与痛风流行病学调查

目的 对山东省海阳市沿海5个社区年龄≥20岁居民的高尿酸血症与痛风的发病情况进行调查，并分析其影响因素。方法采用统一的调查表对5372名居民进行调查，调查内容包括职业、性别、年龄、食用海产品情况、饮酒史、血尿酸值。对高尿酸血症者测量身高、体重、血压，对痛风患者进行血脂、血糖、肾功能及泌尿系统B超检查。结果高尿酸血症患病率男性为16．85％（424／2517），女性为7．88％（225／2855），男女合计为12．08％（649／5372）。发现痛风患者23例，男性21例，患病率为0．83％（21／2517）；女性2例，患病率为0．07％（2／2855）；男女合计为0．43％（23／5372）。相关因素分析显示，男性、女性高尿酸血症组与在性别和年龄上相匹配的健康对照组比较，体重指数、高血压患病率、食用海产品史、男性饮酒史差异均有统计学意义（P〈0．01或0．05）。结论沿海社区居民高尿酸血症和痛风患病率较高，体重指数、高血压、饮酒和食用含高嘌呤海产品等为高尿酸血症相关危险因素。

An epidemiologic study on hyperuricaemia and gout in residents of coastal areas of Haiyang City in Shandong

Objective To investigate the prevalence of hyperuricaemia and gout in the residents aged over 20 years and living in the coastal areas of Haiyang City of Shandong Province,and their related factors. Methods Investigation was performed in 5 372 residents with a standard questionnaire,including occupation,gender,age,seafood consumption, alcohol drinking,and blood uric acid measurement. Body weight,height and blood pressure were measured for those with hyperuricemia,and blood lipid and sugar levels and renal function were measured,and B-type ultrasonography for the urinary system was performed for those with gout.Results Prevalence of hyperuricaemia was 12.08%(649/ 5 372), 16.85% (424/2 517) in men and 7.88% (225/2 855) in women,repectively.In total,23 cases of gout were detected from 5 372 residents,21 in men (0.83%,21/2 517) and two in women (0.07%,2/2 855),respectively. Univariate analysis showed that there was significant difference in BMI,prevalence of hypertension and seafood consumption between those with and without hyperuricaemia,matched on gender and age,either in men or in women,but the difference in alcohol drinking could only be found in men (P<0.01 or 0.05). Conclusions Prevalence of hyperuricaemia in the residents living in the coastal areas was higher,and their body mass index (BMI),prevalence of high blood pressure, alcohol drinking and consumption of seafood with high-purine content were risk factors for hyperuricaemia.