CORAL AS A CARRIER FOR RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 |
| |
Authors: | Zhang Senlin Mao Tianqiu Meng Zhaoye Wang Huixin |
| |
Institution: | Department of Stomatology, Nanjing General Hospital of PLA, Nanjing 210002. |
| |
Abstract: | By combining coral with recombinant human bone morphogenetic protein-2 (rhBMP-2), rhBMP-2/coral composite was obtained in this study. Following implantation of the composite into the muscle pouches of mice, cartilage growth was induced in the pores or on the surface of the implants at one week, woven bone at three week and lamellar bone with bone marrow at six week, and coral was absorbed partially. The induced formation of endochondral bone was time-related and rhBMP-2 dose-related. The results of this study indicate that the composite possesses a superior ability of osteogenesis, and coral acts as one of the most suitable rhBMP-2 slowrelease carriers currently available. The composite will be a new type of bone substitute to be used in orthopaedics and maxillofacial surgery. |
| |
Keywords: | recombinant human bone morphogenetic protein-2 osteoinduction carrier |
本文献已被 CNKI 维普 等数据库收录! |
|