Stimulation of a bulbospinal 5-HT pathway in the rat brain produces hyperglycaemia |
| |
| Authors: | L R Shian M -T Lin |
| |
| Institution: | (1) Department of Internal Medicine, National Defence Medical Centre and Tri-Service General Hospital, Taipei, Taiwan, Republic of China;(2) Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China |
| |
| Abstract: | The glucoregulatory role of spinally projecting serotonin (5-HT) neurones near the ventrolateral surface of the medulla oblongata was investigated by stimulating these nerve cells in normal rats and in rats with selective chemical ablation of 5-HT nerves in the spinal cord. Electrical stimulation of the lateral medulla produced hyperglycaemia in normal rats; the increase in blood glucose was proportional to the intensity and frequency of stimulation. Furthermore, microinjection of kainic acid or L-glutamate at the same sites also produced hyperglycaemia. This stimulation-induced hyperglycaemia was significantly reduced by spinal transection or adrenalectomy. Selective destruction of spinal 5-HT nerves produced by intraspinal injection of 5,7-dihydroxytryptamine also reduced the magnitude of the hyperglycaemia response to electrical stimulation of the lateral medulla. This indicates that stimulation of 5-HT nerve cells adjacent to the ventrolateral surface of the medulla oblongata and projecting to the spinal cord increases the adrenal-sympathetic efferent activity and leads to hyperglycaemia in rats. |
| |
| Keywords: | Glucoregulation Spinal serotonin nerves Electrical stimulation Ventrolateral medulla 5 7-Dihydroxytryptamine |
| 本文献已被 SpringerLink 等数据库收录！ |
|
