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Breast fibroblasts modulate epithelial cell proliferation in three-dimensional <Emphasis Type="Italic">in vitro</Emphasis> co-culture |
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| Authors: | Andrea?Sadlonova Zdenek?Novak Martin?R?Johnson Damon?B?Bowe Sandra?R?Gault Grier?P?Page Jaideep?V?Thottassery Danny?R?Welch |
| Institution: | (1) Department of Pathology, The University of Alabama at Birmingham, Alabama, USA;(2) Department of Pediatrics, The University of Alabama at Birmingham, Alabama, USA;(3) Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Alabama, USA;(4) Department of Biostatistics, The University of Alabama at Birmingham, Alabama, USA;(5) Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA |
| Abstract: | BackgroundStromal fibroblasts associated with in situ and invasive breast carcinoma differ phenotypically from fibroblasts associated with normal breast epithelium, and these alterations in carcinoma-associated fibroblasts (CAF) may promote breast carcinogenesis and cancer progression. A better understanding of the changes that occur in fibroblasts during carcinogenesis and their influence on epithelial cell growth and behavior could lead to novel strategies for the prevention and treatment of breast cancer. To this end, the effect of CAF and normal breast-associated fibroblasts (NAF) on the growth of epithelial cells representative of pre-neoplastic breast disease was assessed. |
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