| 橄榄油对氟比洛芬和双氯芬酸钠大鼠经皮吸收的影响 |
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| 引用本文： | 王爱萍,万 芳,梁荣才,陈大全,慕宏杰. 橄榄油对氟比洛芬和双氯芬酸钠大鼠经皮吸收的影响[J]. 医学教育探索, 2012, 27(3): 223-225 |
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| 作者姓名： | 王爱萍 万 芳 梁荣才 陈大全 慕宏杰 |
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| 作者单位： | 1. 烟台大学 药学院，山东 烟台 264005; 2. 山东绿叶制药有限公司，山东 烟台 264003;青岛华钟制药有限公司，山东 青岛 266100;烟台大学 药学院，山东 烟台 264005 |
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| 摘 要： | 目的 考察橄榄油对氟比洛芬和双氯芬酸钠透过大鼠腹部皮肤的作用。方法 以离体大鼠腹部皮肤为渗透屏障，采用扩散池装置，以预处理皮肤法考察橄榄油对药物透过皮肤的影响。结果 橄榄油可有效促进氟比洛芬的经皮透过率，增渗倍数为2.11，但对双氯芬酸钠的经皮透过率有抑制作用。结论 橄榄油能够促进氟比洛芬的经皮渗透，可能归因于其中油酸的存在，还可能含有某些成分对双氯芬酸钠的经皮渗透有抑制作用。
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| 关 键 词： | 氟比洛芬；双氯芬酸钠；橄榄油；经皮吸收 |
Effect of olive oil on percutaneous of flubiprofen and diclofenac sodium in rats |
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| WANG Ai-ping,WAN Fang and LIANG Rong-cai,CHEN Da-quan,MU Hong-jie. Effect of olive oil on percutaneous of flubiprofen and diclofenac sodium in rats[J]. Researches in Medical Education, 2012, 27(3): 223-225 |
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| Authors: | WANG Ai-ping WAN Fang LIANG Rong-cai CHEN Da-quan MU Hong-jie |
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| Affiliation: | 1. School of Pharmacy, Yantai University, Yantai 264005, China 2. Shandong Luye Pharmaceutical Co. Ltd., Yantai 264003, China;Qingdao Huazhong Pharmaceuticals Ltd., Qingdao 266100, China;Shandong Luye Pharmaceutical Co. Ltd., Yantai 264003, China |
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| Abstract: | Objective To examine the effect of olive oil on percutaneous absorption of flubiprofen and diclofenac sodium in rats. Methods The rat skin was applied as barrier, and diffusion cell was used. Effects of olive oil on pretreatment of pretreated skin were studied. Results Olive oil could effectively enhance the permeation of flubiprofen with the enhancement ratio of 2.11, while it suppressed the percutaneous absorption of diclofenac sodium. Conclusion Olive oil could be an effective percutaneous absorption enhancer for flubiprofen because of its oleic acid, and its suppression for diclofenac sodium can also be worthy of exploitation. |
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| Keywords: | flubiprofen diclofenac sodium olive oil percutaneous absorption |
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