单采浆人群中HIV、HCV感染的历史性队列研究

目的了解既往单采浆人群中HIV/HCV共感染的流行特征;HCV合并感染对HIV感染者的影响;评估抗逆转录病毒治疗的效果。方法对既往单采浆献血员及其密切接触者进行回顾性调查,检测HIV抗体、HCV抗体。并用χ2检验比较病死率和生存率。结果HIV/HCV共感染与单独HIV感染者的发病率差异有统计学意义（P〈0.001）。抗病毒治疗前后病死率差异有统计学意义（P〈0.001）。HIV/HCV共感染与HIV单独感染者的病死率差异无统计学意义（P〉0.05）。结论HIV/HCV共感染可能增加HIV感染者发病的危险。对HIV/HCV共感染者给予更多关注。实施干预措施可以有效降低患者的病死率。应对艾滋病患者积极开展抗逆转录病毒治疗。

Historical cohort study on the HIV/HCV co-infections In formal plasma donors

Objective To investigate the prevalence of HIV/HCV co infections in formal plasma donors （FPD）, and evaluate the effects of HIV/HCV co-infections in HIV infected individuals and the effects of HAART. Methods FPD and those close to them were under a retrospective cohort study, tested for anti-HIV and anti-HCV. Significance was determined by χ^2 test using SPSS 13.0. Results The incidence rate in HIV/HCV co infection was significantly higher than HCV seronegativity individuals （ P 〈 0.001 ）, and the fatality rate was a significant difference （ P 〈 0.001 ） between individuals with HAART and those without. The fatality rate in HIV/HCV co-infection was not significantly higher than HCV seronegativity individuals （ P 〉 0.05 ）. Couclusions HCV could be an important factor in the morbidity and mortality among HIV infected individuals. But the probability of progression to death is not associated with HCV seropositivity. More attention should be paid to HIV/HCV co-infection individuals. The beneficial effects of HAART are confirmed. Effective interference has very important significance in HIV-infected patients. HAART should be carried out actively in HIV infected patients.