| 附睾蛋白酶抑制蛋白的研究进展 |
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| 引用本文： | 郭晓强,王仁杰. 附睾蛋白酶抑制蛋白的研究进展[J]. 中华男科学杂志, 2005, 11(11): 851-853 |
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| 作者姓名： | 郭晓强 王仁杰 |
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| 作者单位： | 解放军白求恩军医学院生物化学教研室,河北,石家庄,050081 |
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| 摘 要： | 附睾蛋白酶抑制蛋白(Eppin)基因是最近克隆到的一种人类和小鼠附睾和睾丸中特异性表达的基因。Epp in蛋白是一种富含半胱氨酸同时含有乳清酸蛋白(WAP)和牛胰蛋白酶抑制蛋白(BPTI)结构域的分泌蛋白,它与精子成熟和生殖有关,此外还参与了人类附睾的天然免疫系统。针对Epp in蛋白的免疫避孕是一种有效和安全的方式,但还需进一步验证它的安全性。本文就Epp in的生殖和免疫功能及在免疫避孕中的应用进行综述。
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| 关 键 词： | 附睾蛋白酶抑制蛋白 精子成熟 免疫避孕 |
| 文章编号： | 1009-3591（2005）11-0851-03 |
| 收稿时间： | 2004-11-26 |
| 修稿时间： | 2005-03-30 |
Advances in the Study of Epididymal Protease Inhibitor |
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| GUO Xiao-qiang,WANG Ren-jie. Advances in the Study of Epididymal Protease Inhibitor[J]. National journal of andrology, 2005, 11(11): 851-853 |
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| Authors: | GUO Xiao-qiang WANG Ren-jie |
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| Affiliation: | Department of Biochemistry, Bethune Military Medical College, PLA , Shijiazhuang , Hebei 050081, China |
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| Abstract: | The epididymal protease inhibitor(Eppin) has recently been cloned in human and mice,which is specifically expressed in the epididymis and testis.Eppin is a cystine-rich secretory protein which contains signal peptide,WAP and BPTI motifs.Eppin is involved in sperm maturation and fertilization,and in the innate immune system of human epididymis.Immunocontraception with Eppin is effective and reliable,but its safety is to be further proved.This paper summarizes the effects of Eppin of fertilization and immunity,as well as its utilization in immunocontraception.Natl J Androl,2005,11(11):851-853 |
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| Keywords: | epididymal protease inhibitor sperm maturation immunocontraception |
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