Behavioral and electrographic effects of opioids on kindled seizures in rats |
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Authors: | S. Caldecott-Hazard Y. Shavit R.F. Ackermann J. Engel Jr. R.C.A. Frederickson J.C. Liebeskind |
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Affiliation: | MRC Neurochemical Pharmacology Unit, Medical Research Council Centre, Medical School, Hills Road, Cambridge CB2 2QH U.K. |
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Abstract: | The origin of the substance P-like immunoreactivity in the rat submandibular gland and its major duct was investigated. Lesions severing the sympathetic, pre- and postganglionic parasympathetic and sensory innervation of the submandibular gland, or treatment with the neurotoxin capsaicin produced only a small non-significant decrease in the substance P-like immunoreactivity content of the gland. In contrast both sensory denervation and capsaicin treatment produced a substantial decrease in the content of substance P-like immunoreactivity in the major duct of the submandibular gland. These observations indicate that the duct innervation is clearly of sensory origin, whilst the substance P-like immunoreactivity of the gland itself appears to be intrinsic. |
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Keywords: | kindled seizure morphine enkephalin analogue anticonvulsant effect afterdischarge enhancement |
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