| 未变性乳清蛋白佐治单纯型肾病综合征的疗效 |
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| 引用本文： | 张成,李彬,冼玉玲,欧兴义. 未变性乳清蛋白佐治单纯型肾病综合征的疗效[J]. 实用儿科临床杂志, 2007, 22(5): 379-380 |
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| 作者姓名： | 张成 李彬 冼玉玲 欧兴义 |
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| 作者单位： | 暨南大学附属第三医院,儿科,广东,珠海,519000 |
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| 摘 要： | 目的研究未变性乳清蛋白对单纯型肾病综合征(NS)的疗效及可能机制。方法将36例NS患儿随机分为2组。对照组单用泼尼松口服治疗,治疗组在激素治疗基础上加用未变性乳清蛋白治疗,随访观察1年,观察指标为复发及上呼吸道感染频率,并动态检测红细胞浆还原型谷胱甘肽(GSH)水平。结果未变性乳清蛋白可有效提高单纯性NS患儿红细胞浆GSH水平,治疗组的复发频率及上呼吸道感染频率均较对照组明显减少。结论未变性乳清蛋白可有效减少肾病复发,其机制与提高细胞GSH水平进而改善抗氧化能力有关。
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| 关 键 词： | 未变性乳清蛋白 还原型谷胱甘肽 肾病综合征 儿童 |
| 文章编号： | 1003-515X(2007)05-0379-02 |
| 修稿时间： | 2007-01-20 |
Curative Effect of Underatured Lactalbumin Treatment in Children with Nephrotic Syndrome |
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| ZHANG Cheng,LI Bin,XIAN Yu-ling,OU Xing-yi. Curative Effect of Underatured Lactalbumin Treatment in Children with Nephrotic Syndrome[J]. Journal of Applied Clinical Pediatrics, 2007, 22(5): 379-380 |
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| Authors: | ZHANG Cheng LI Bin XIAN Yu-ling OU Xing-yi |
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| Affiliation: | Department of Pediatrics, the Third Affiliated Hospital of Jinan University, Zhuhai 519000, China |
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| Abstract: | Objective To investigate the clinical efficacy of nephrotic syndrome in children adjunctively treated by underatured lactalbumin.Methods Thirty-six cases of nephrotic syndrome were studied for about 1 year.The changes in red blood cells of reduced glutathione(GSH) were analyzed in 18 cases of underatured lactalbumin treatment group and 18 cases of control group.The clinical presentations were observed in both groups.Results GSH levels increased in underatured lactalbumin treatment group when compared with control group.The frequency of relapse and upper respiratory tract infection in underatured lactalbumin treatment group were significantly reduced compared with control group.Conclusion Underatured lactalbumin can provide support for the potential use of an antioxidant therapy in these patients. |
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| Keywords: | underatured lactalbumin reduced glutathione nephrotic syndrome child |
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