128例药物性肝病分析

目的对药物性肝病的临床特点进行分析。方法回顾性分析128例药物性肝病患者的临床资料。结果导致药物性肝病的药物种类繁多,其中中草药及中成药（25.00%）、抗结核药（20.31%）所占比例最多;肝细胞型患者75例,胆汁淤滞型36例,混合型17例;128例患者发病时间,〈1周患者5例,1～5周患者11例,6～12周患者46例,13～19周患者35例,20～26周患者7例,27～33周患者15例,〉33周患者9例;115例患者预后良好,其余13例预后欠佳,其中12例发生重型肝炎,1例死亡。结论中草药及中成药和抗结核药是引起药物性肝病的主要药物,应定期检测肝功能。

Clinical analysis of 128 cases with drug-induced liver disease

Objective To study the clinical features of drug-induced liver disease.Methods The clinical data of 128 cases with drug-induced liver disease were retrospectively analyzed.Results There were various drugs which could result in drug-induced liver disease,with the traditional Chinese medicines(25.00%) and anti-tuberculosis drugs(20.31%) taking the maximum of proportion.There were 75 cases with liver cell type,36 cases with bile stasis type,and 17 cases with the mixed type.As to the onset time,there were 5 cases(< 1 week),11 cases(1-5 week),46 cases(6-12 week),35 cases(13-19 week),7 cases(20-26 week),15 cases(27-33 week) and 9 cases(> 33 week).115 cases had good prognosis,while the other 13 cases had bad prognosis including 12 patients with severe hepatitis and one death.Conclusion Traditional Chinese medicines and anti-tuberculosis drugs are the main kinds of drugs,which can cause drug-induced liver disease,and the liver function of patients taking these drugs should be regularly detected.