氟伐他汀对不稳定心绞痛患者C-反应蛋白的影响

目的　观察氟伐他汀对不稳定心绞痛患者C 反应蛋白的影响。方法　将 5 6例不稳定心绞痛患者随机分为 2组 ,对照组给予常规治疗 ,治疗组在常规治疗的基础上加氟伐他汀每日 2 0mg ,晚餐后服用 ,疗程共 4周。治疗前后检查C 反应蛋白水平和血脂水平。结果　治疗后治疗组C 反应蛋白水平明显降低 ,与对照组相比差异显著(P <0 .0 1 )。而血脂水平无明显变化。结论　氟伐他汀可以显著降低C 反应蛋白水平 ,具有抗炎作用 ,这种作用独立于降脂作用。

Effect of fluvastatin on C-reactive protein in patients with unstable angina

Objective To investigate the effect of fluvastatin on C reactive protein in patients with unstable angina.Methods Fifty six patients were randomly divided into control group ( n =30 conventional therapy) and treatment group ( n =26 conventional therapy added to fluvastatin 20mg,ones a day,taken after dinner for 4 weeks).CRP level and lipid level were measured before and after treatment.Results After treatment the CRP level in treatment group was lower than that of control group.The difference was significant statistically ( P <0.01).There was no difference of lipid level between two groups.Conclusion Fluvastatin reduce CRP level significantly.It has the anti inflammatory effect which is independent of lipid lowering effect.