大鼠失血性休克和输血后心房心肌细胞超微结构改变的初步观察

本文对大鼠失血性休克和输血后心房心肌细胞超微结构的改变进行了观察。实验动物分为对照组、失血性休克组及输血组。结果表明,失血性体克对心房心肌细胞超微结构的影响主要表现在心房特殊颗粒显著增多,而输血后则可使心房心肌细胞的超微结构发生较明显的改变,除线粒体肿胀、线粒体嵴减少、灶性空化,基质内出现髓鞘样结构、肌浆网扩张,Gagli复合体、核周隙扩张以及心肌闰盘分离外,其特殊的变化是心房特殊颗粒显著减少。本文研究提示,心房心肌细胞参与了失血性休克和输血后的发病过程。

Preliminary observations on ultrastructural changes of atrial myocardial cells during hemorrhagic shock and after autotrans-fusion in rats

The ultrastructural changes of atrial myocardial cells during hemorrhagic shock and after autotransfusion with the shedded blood were observed in rats,which were divided into control,hemorrhagic shock and auspeto-transfusion groups.It was found that there was a marked increase of atrial specific granules in the atrial myocardial cells during hemorrhagic shock.Striking ultrastructural changes of atrial myocardial cells were noted after transfusion of the shedded blood.Reduction in the number of atrial specific granules,in addition to mitochondrial swelling,reduction of the cristae,focal emptying of mitochondria,myelin-like figure in mitochondrial matrix,expansion of sar-coplasmic reticulum,dilatation of Golgi complexes and perinuclear space,and dissociation of myocardial disk,were remarkable.The findings suggest that atrial myocardila cells participate in the patho-physiological changes of hemorrhagic shock and autotransfusion.