银杏露急性毒性及长期毒性试验

目的：观察小鼠一日内给予较大剂量的银杏露时的急性中毒及死亡情况。及连续重复给予银杏露对大鼠所产生的毒副作用情况，为拟定人用安全剂量提供参考。方法：急性毒性试验为测定小鼠最大给药量方法，长期毒性试验为大鼠连续以银杏露60、30、15g(生药）/ml灌胃给药，观察小鼠各项有利生理，病理指标的方法。结果：银杏露对小鼠一日内灌胃的最大药量为240g(生药）/kg，大鼠长期毒性试验结果显示银杏露对大鼠的体重，活动情况，进食量，外表体征，血象，血液生化，脏器系数，病理检查等指标等均无不良影响。结论：银杏露按拟定临床剂量及疗程服用是安全的。

A test of acute toxicity and long-term toxicity of Yinxing lu

OBJECTIVE:To investigate the acute toxicity and death of the mice to which Yinxing Lu was given in much less dose and the toxic effects of the rats to which Yinxing Lu was given in constant dose, in order to offer reference of the safe dose for men.METHOD:The acute toxicity test was to determine the maximun dose for the mice. The long term toxicity test was to investigate all beneficial physiologic and pathologic indexes of the mice to which Yining Lu was given intragastrically in 60,30,15g(herb)/ml.RESULTS:The maximum dose for the mice was 240g(herb)/kg per day. The test results of long term toxicity in the rats indicated that Yinxing Lu had no harmful effect on the rats in the follwing indexes:body weight, exercises, food eating quantity, signs, hemogrotm, blodbiochemistry, organs facter, pathologic examination.CONCLUSION:It was saft to take Yinixing Lu with the dose described and course of treatment.