^99mTc—DTPA肾动态显像法测定健康人GFR的研究

【目的】观察^99mTc—DTPA肾动态显像法测定健康人肾小球滤过率（GFR）的正常值，以及健康人随着年龄增长GFR值的变化。【方法】通过询问病史，测量血压，测定空腹血糖、血脂、血肌酐、尿常规、尿蛋白4项、24h尿蛋白定量，尿沉渣镜检，肾脏超声及肾穿刺病理结果，严格制定入选标准及排除标准，并采用放射性核素显像测定GFR。【结果】健康成人的平均GFR值为（87．68±16．74）mL／（min·1．73m^2），142例受试者按年龄段分为20～，30～，40～，50～四组。相同年龄组中不同性别GFR值差异无统计学意义，男性各年龄组的GFR值差异无统计学意义。在〉50岁女性的GFR和≤50岁女性各年龄组的GFR比较有统计学意义，且〉50岁女性的GFR呈明显下降，与40～，30～，20～组比较分别是（83．36±10．15）mL／（min·1．73m^2）vs（95．32±13．91）mL／（min·1．73m^2），（91．24±16．46）mL／（min·1．73m^2），（98．92±11．35）mL／（min·1．73m^2）。【结论】^99mTc—DTPA肾动态显像法测定健康人GFR不同于西方人，女性的GFR在〉50岁表现出较明显的下降的趋势。

Study on 99mTc-DTPA Renal Dynamic Imaging for Detecting Glomerular Filtration Rate in Healthy People

[Objective] To observe the normal value of glomeruiar filtration rate（GFR） in healthy people detected by ^99 mTc-DTPA renal dynamic imaging and its change with the age. [Methods] The case history was inquired. Blood pressure, fasting blood glucose, lipids and serum creatinine were determined. Urine routine test, urine proteins and 24h-urinary protein quantitive test, urinary sediment microscopic examination, renal ultrasound and renal biopsy were performed. The selection and exclusion criteria were strictly formulated. Radionuclide imaging was used to detect the GFR. [Results]The average GFR value in the healthy adults was （87.68±16.74）mL/（min · 1.73 m^2 ）. There was no significant difference in GFR of different gender in the same age group. There was no significant difference in GFR in men among different age groups. There was significant different in GFR between women aged more than 50 years old and women aged less than 50 years old[（83.36±10.15）mL/（min · 1.73 m^2）, （95.32±13.91）mL/（min · 1.73 m^2）, （91.24± 16.46）mL/（min · 1.73 m^2）, （98. 92± 11. 35）mL/（min · 1. 73 m^2）]. [Conclusion]The GFR in healthy people detected by ^99mTc-DTPA renal dynamic imaging is different from that in western people. The GFR in women aged over 50 years old has a trend of decline.