TNF-α和IL-6血清检测在儿童急性病毒性心肌炎诊断中的价值

目的探讨急性病毒性心肌炎患儿血清肿瘤坏死因子-α（TNF-α）及白介素-6（IL-6）水平变化及其临床价值。方法应用放射免疫法（RIA）和酶联免疫法（EIISA），检测53例急性病毒性心肌炎患儿及20名健康儿童血清中TNF—α及IL-6含量。结果心肌炎组血清TNF—α和IL-6水平分别为（526．7±32．9）mg／L和（3．23±0．53）mg/L，而健康组分别为（383．1±27．5）mg／L和（1．63±0．22）mg／L，二者相比差异有统计学意义（P〈0．05）；临床治愈后，心肌炎组TNF—α及IL-6分别降至（407．3±34．4）mg／L和（1．97±0．29）mg／L，与正常组相比差异无统计学意义（P〉0．05）。结论检测TNF—α及IL-6血清水平及其变化，有助于判断急性病毒性心肌炎患儿病情及心肌损害程度。

Clinical value of changes of tumor necrosis factor-a and interleukin-6 level in the children with acute viral myocarditis

Objective To assess the clinical value of changes of tumor necrosis factor-α and interleukin- 6 level in the children with acute viral myocarditis （AVM）. Methods TNF-α and IL-6 levels in serum from 53 viral myocarditis children and 20 healthy children were measured by radio-immunoassay（RIA） and enzyme-linked immunosorbent assy （EIISA）, and then analysed the correlation between the levels of TNF-α and IL-6 in serum and the occurance and development in acute viral myocarditis. Results The serum levels of TNF-α and IL-6 of the AVM group were much higher than those of the control group（P〈0.05）, there was no obvious difference of the serum level of TNF-α and IL-6 between the patients after AVM clinical recovery and the normals. Conclusion Determination of TNF-α and IL-6 levels is useful to judge the severity of AVM and its heart damage.