盐酸羟考酮缓释片与盐酸曲马多缓释片治疗癌痛疗效比较

目的：比较盐酸羟考酮缓释片和盐酸曲马多缓释片治疗中度癌痛的疗效和安全性。方法：中度癌痛患者290例随机分为观察组148例与对照组142例。观察组口服盐酸羟考酮缓释片,对照组口服盐酸曲马多缓释片治疗,疗程2周。比较两组患者镇痛总有效率和不良反应发生情况。结果：观察组与对照组镇痛总有效率分别为92.6%和81.7%,差异有统计学意义（P〈0.01）;药品不良反应发生率分别为60.1%和57.0%,差异无统计学意义（P〉0.05）。结论：盐酸羟考酮缓释片治疗中度癌痛患者优于盐酸曲马多缓释片。

Effect Comparison of Oxycodone Hydrochloride Prolonged release Tablets and Tramadol Hydrochloride Sustained release Tablets in the Treatment of Cancer Pain

Objective： To investigate the efficacy and safety of oxycodone hydrochloride prolonged-release tablets and tramadol hydrochloride sustained-release tablets in the treatment of moderate cancer pain. Methods： Totally 290 cases of the patients with moderate pain were divided into the observation group with 148 cases and the control group with 142 cases. The observation group received oxycodone hydrochloride prolonged-release tablets,while the control group was given tramadol hydrochloride sustained-release tablets.The treatment course was 2 weeks,and the total efficiency and the incidence of adverse drug reactions（ ADR） in the two groups were calculated and compared. Results： The total efficiency in the observation group and the control group was 92. 6% and 81. 7%,respectively,and the difference was statistically significant（ P〈0. 01）. The incidence of ADR was 60. 1% and 57%,respectively with no significant difference（ P〉0. 05）. Conclusion： The effect of oxycodone hydrochloride prolonged-release tablets in the treatment of moderate cancer pain is better than that of tramadol hydrochloride sustained-release tablets.