| 儿童肾病综合征T细胞亚群检测的临床意义 |
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| 引用本文： | 翁志媛,钟志敏,于力,黄逸辉,张又祥. 儿童肾病综合征T细胞亚群检测的临床意义[J]. 中国中西医结合肾病杂志, 2003, 4(3): 148-149 |
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| 作者姓名： | 翁志媛 钟志敏 于力 黄逸辉 张又祥 |
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| 作者单位： | 1. 广东省广州市第一人民医院儿科,广州,510180
2. 广东省广州市第一人民医院检验科,广州,510180 |
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| 基金项目： | 广东省中医药管理局科研基金资助部分项目 (No .99170 ) |
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| 摘 要： | 目的：探讨儿童原发性肾病综合征（NS）T细胞亚群检测的临床意义。方法：对25例NS活动期和缓解期患儿应用流式细胞仪检测T2细胞亚群的变化。结果：NS活动期组CD3^ ,CD4^ ,CD4^ /CD8^ 比值，NK[CD(16 56)]^ 细胞均明显低于缓解期组（P＜0．01）和对照组（P＜0．01）。结论：说明NS细胞免疫功能减低，T细胞亚群检测可作为肾病综合征活动指标之一。
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| 关 键 词： | 检测 临床意义 肾病综合征 T细胞亚群 免疫 |
| 修稿时间： | 2002-08-31 |
Clinical Significance of Measuring T Lymphocyte Subsets in Children with Nephrotic Syndrome |
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| WENG Zhiyuan,ZHONG Zhimin,YU Li,et al. Clinical Significance of Measuring T Lymphocyte Subsets in Children with Nephrotic Syndrome[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2003, 4(3): 148-149 |
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| Authors: | WENG Zhiyuan ZHONG Zhimin YU Li et al |
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| Abstract: | Objective:To study the clinical significance of measuring T lymphocytes subsets in children with nephrotic syndrome(NS).Methods:T lymphocyte subsets were measured by flow cytometry. Change in T lymphocyte subset in the blood was measured in 25 children with nephrotic syndrome in active stage and 20 in remission stage.Results:The percentages of CD 3 + cell, CD 4 +cell,CD (16+56) +cell and the ratio of CD 4 +/CD 8 +were significantly lower in NS active stage than those in remission and in control group (both P <0.01).Conclusion:Cellular immunity in NS patients was impaired. T lymphocytes subsets can be used as an index of activity in nephrotic syndrorne. |
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| Keywords: | Nephrotic syndrome T lymphocytes subsets Immunity |
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