Herbal teas interfere with cyclosporin levels in renal transplant patients. |
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| Authors: | Rainer Nowack Barbara Nowak |
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| Affiliation: | Dialysis-Center, Lindau/Bodensee, Germany. info@dialyse-lindau.de |
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| Abstract: | | Introduction | After a successful renal transplantation, a high fluid intakeof 23 l daily is generally advised to achieve a steadyurine flow. To reach that goal, dieticians recommend herbalteas, since they regard them as biologically inert; in contrastto black tea, coffee, alcoholics or commercial fruit juices,which are either psychotropic or rich in calories. However, herbal teas contain plant constituents of biologicalrelevance for the consumer, and especially for transplantedpatients treated with immunosuppressive medication. We present here three renal transplant patients who drank herbalteas with a marked influence on cyclosporin metabolism. Cases | The first patient was a 48-year-old woman (weight 56 kg, height165 cm) who received a cadaveric renal allograft in September2000. After two severe rejection episodes, graft function hadstabilized at a serum creatinine of 1.21.4 mg/dl andshe received maintenance immunosuppression with cyclosporin,mycophenolate mofetil (MMF) and tapered steroids which
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| Keywords: | cyclosporin cytochrome P450 enzymes herbal teas herb– drug interaction pharmacokinetics |
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