| 西比灵对大鼠急性脑缺血再灌注损伤自由基影响的实验研究 |
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| 引用本文： | 刘松岩,于挺敏,邬英全,刘淑玲,迟春萍. 西比灵对大鼠急性脑缺血再灌注损伤自由基影响的实验研究[J]. 中国老年学杂志, 2000, 20(3): 179-180 |
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| 作者姓名： | 刘松岩 于挺敏 邬英全 刘淑玲 迟春萍 |
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| 作者单位： | 1. 白求恩医科大学中日联谊医院神经内科,长春,130031
2. 卫生部长春生物制品研究所病毒研究室 |
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| 摘 要： | 目的 进一步探讨西比灵对脑缺血再灌注损伤保护作用的机制。方法 采用Ｐｕｌｓｉｎｅｌｉ四血管闭塞法（４ＶＯ）缺备大鼠急性脑缺血再灌注模型，利用Ｔｓｕｃｈｉｄａ的ＷＰＳ法测定ＬＰＯ，利用化学发光法测定ＳＯＤ活性，并观察西比灵对上述指标的影响。结果 西比灵可降低ＬＰＯ含量，稳定ＳＯＤ活性。结论 西比灵可抑制脑缺血再灌注时脑组织内自由基的生成。
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| 关 键 词： | 急性脑缺血 再灌注损伤 自由基 西比灵 实验研究 |
| 修稿时间： | 1999-04-11 |
The effects of sibelium on the free radicals after acute cerebral ischemia reperfusion injury of the rats |
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| Liu Songyan,Liu Shuting,Yu Tingmin et al. The effects of sibelium on the free radicals after acute cerebral ischemia reperfusion injury of the rats[J]. Chinese Journal of Gerontology, 2000, 20(3): 179-180 |
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| Authors: | Liu Songyan Liu Shuting Yu Tingmin et al |
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| Abstract: | Objective To study the protective effect of sibelium to acute cerebral ischemia reperfusion injury. Mathods Acute cerebral ischemia reperfusion rat model were prepared by pulsinelli's 4VO method. to assay LPO,Tsuchida's WSPS method,was used and SOD activity was assayed by chemiluminescence method to observe sibelium's influence on these indices. Results Sibelium can decrease LPO content,stabilize SOD activity and sibelium can also inhibit free radical production during cerebral ischemia reper fusion. Conclusions Sibelium can protect brain tissue during reper fusion after cerebral ischemia. |
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| Keywords: | Cerebral ischemia reperfusion LPO SOD Sibelium Free radical |
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