Clinical variables and hypothalamic-pituitary-adrenal function in depression. The importance of mood reactivity |
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Authors: | C Z Lemus G M Asnis U Halbreich J M Harkavy Friedman H M Van Praag E Rubinson J Eisenberg |
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Affiliation: | 1. School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China;2. Department of Pathology, School of Basic Medicine, Anhui Medical University, Hefei 230032, Anhui, China |
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Abstract: | Forty outpatients with major depressive disorder were studied with the 1 mg DST and the Afternoon Cortisol Test. No relationship was found between hypothalamic-pituitary-adrenal (HPA) axis function and Research Diagnostic Criteria subtypes of depression, with the exception of higher log post-dexamethasone cortisol levels in endogenous depressives. Patients with mood reactivity had lower cortisol values on all assessments. The data suggest that the presence of mood reactivity may be useful as a predictor of normal HPA function in depression. |
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