Frequency of vacA Genotypes and Cytotoxin Activity in Helicobacter pylori Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma |
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| Authors: | Stephan Miehlke, Alexander Meining, Andrea Morgner, Ekkehard Bayerd rffer, Norbert Lehn, Manfred Stolte, David Y. Graham, Mae F. Go |
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| Affiliation: | Stephan Miehlke, Alexander Meining, Andrea Morgner, Ekkehard Bayerdörffer, Norbert Lehn, Manfred Stolte, David Y. Graham, and Mae F. Go |
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| Abstract: | The vacA genotypes s1,m1 and s1,m2 were detected in 44 and 30% of Helicobacter pylori isolates, respectively, from patients with gastric mucosa-associated lymphoid tissue lymphoma, compared to 26 and 56% of isolates, respectively, from individuals with gastritis. The vacA s1 genotype was significantly associated with, but not predictive of, the presence of vacuolating cytotoxin activity. |
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