| 重组人白细胞介素-11对非髓性恶性肿瘤化疗导致血小板减少者的临床应用 |
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| 引用本文： | 冯莹,叶絮,庞缨,蔡晓东,李澄宇,谭获,赖毅妍,周旭红. 重组人白细胞介素-11对非髓性恶性肿瘤化疗导致血小板减少者的临床应用[J]. 血栓与止血学, 2004, 10(3): 123-125 |
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| 作者姓名： | 冯莹 叶絮 庞缨 蔡晓东 李澄宇 谭获 赖毅妍 周旭红 |
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| 作者单位： | 广州医学院第二附属医院血液科,广州,510260 |
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| 摘 要： | 目的:观察重组人白细胞介素-11(rh-IL-11)在实体瘤中、强度化疗后的促血小板增殖作用及不良反应,评价其临床疗效和安全性。方法:24例常规化疗的淋巴瘤和3例乳腺癌术后化疗患者,停化疗第4 d起应用rh-IL-11 30-60μg／(kg·d)至血小板数恢复正常,采用自身对照方法,观察血小板计数、疗效不良反应发生情况。结果:rh-IL-11可降低血小板减少症的发生,在本观察组中72.2％不需输注血小板,血小板低谷值持续时间为3-7 d,提升血小板数幅度显著高于自身对照组。结论:rh-IL-11用于非髓性恶性肿瘤的化疗能有效地预防化疗所导致的血小板减少,减少血小板输注,缩短骨髓抑制期。
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| 关 键 词： | 重组人白细胞介素-11 化疗 血小板减少症 |
| 文章编号： | 1009-6213(2004)03-0123-03 |
| 修稿时间： | 2003-04-20 |
Clinical Application of Recombinant Human Interleukin-11 to Prevent Chemotherapy Inducde Thrombocytopenia in Patients with non-Myelogenous Malignanf Tumor |
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| FENG Ying,YE Xu,PANG Ying,CAI Xiao-dong,LI Chen-gyu,TAN Huo,LAIYi-yan,Zhou Xu-hong The Second Affiliated Hospital of Guangzhou Medical College,Guangzhou ,China. Clinical Application of Recombinant Human Interleukin-11 to Prevent Chemotherapy Inducde Thrombocytopenia in Patients with non-Myelogenous Malignanf Tumor[J]. Chinese Journal of Thrombosis and Hemostasis, 2004, 10(3): 123-125 |
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| Authors: | FENG Ying YE Xu PANG Ying CAI Xiao-dong LI Chen-gyu TAN Huo LAIYi-yan Zhou Xu-hong The Second Affiliated Hospital of Guangzhou Medical College Guangzhou China |
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| Affiliation: | FENG Ying,YE Xu,PANG Ying,CAI Xiao-dong,LI Chen-gyu,TAN Huo,LAIYi-yan,Zhou Xu-hong The Second Affiliated Hospital of Guangzhou Medical College,Guangzhou 510260,China |
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| Abstract: | |
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| Keywords: | Recombinant human interluken-11 Chemotherapy Thrombocytopenia |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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