VEGF、CD44v6和MMP-9在食管癌组织中的表达及临床意义

目的:探讨血管内皮生长因子(VEGF)、CD44剪接变体6(CD44v6)和基质金属蛋白酶(MMP)-9在食管癌组织中的表达及其与临床病理特征之间的关系。方法:采用免疫组化方法检测VEGF、CD44v6、MMP-9在45例食管癌患者的手术切除癌组织中的表达。结果:VEGF、CD44v6、MMP-9在食管癌组织中的表达阳性率分别为62．2％、68．9％和42．2％;VEGF、CD44v6表达与肿瘤临床分期、淋巴结转移有关(均P<0．05),与浸润深度、肿瘤大小无关(P>0．05),MMP-9表达与肿瘤临床分期、浸润深度和肿瘤大小有关(P<0．05),与淋巴结转移无关(P>0．05)。结论:VEGF、CD44v6、MMP-9与食管癌临床分期、浸润深度、淋巴结转移关系密切,提示联合检测这3项指标有助于食管癌生物学行为的判断和预后的估计。

Expression and It's Clinical Significance of VEGF, CD44v6 and MMP-9 in Human Esophageal Carcinoma

Objective:To investigate the expression of VEGF, CD44v6 and MMP-9 in human esophageal carcinoma, and its relationship with clinicopathological features of the disease. Methods:Immunohistochemical Envision technique was applied to detect the expression of VEGF, CD44v6 and MMP-9 in 45 specimens of esophageal carcinoma tissues. Results:The positive rate of VEGF, CD44v6, MMP-9 expression were 62. 2%. 68. 9% and 42. 2% respectively;The expression of VEGF, CD44v6 was correlated with TNM stage and lymph node metastasis(P<0. 05) , but wasnt correlated with invasion depth and tumor size(P >0. 05) ;the expression of MMP-9 was correlated with TNM stage, invasion depth and tumor size(P<0. 05), but wasnt related to lymph node metastasis(P>0. 05). Conclusion:The expression of VEGF, CD44v6, MMP-9 is correlated with TNM stage, invasion depth and lymph node metastasis in esophageal carcinoma. Examination of the expression of the three proteins may play an important role in the judgment of the biological behavior and prognosis of esophageal carcinoma.