Lessons from anticancer research might provide new insights into mechanisms of hormone action. |
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Authors: | A R Buckley |
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Affiliation: | College of Pharmacy, University of Cincinnati Medical Center, 3223 Eden Ave, PO Box 670004, Cincinnati, OH 45267-0004, USA. Arthur.Buckley@uc.edu |
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Abstract: | The extent to which specific anticancer drugs induce apoptosis in tumors frequently predicts the success of chemotherapy for a particular type of cancer. Recent results from experiments designed to evaluate drug-induced apoptosis in colon cancer cells revealed that the levels of BCL-2-related apoptotic suppressor proteins were dramatically reduced compared with those of pro-apoptotic proteins. In the case of nonsteroidal anti-inflammatory drugs, this might be a consequence of inhibition of the cyclooxygenase-mediated production of prostaglandins. |
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