布比卡因与不同局麻药联用对臂丛麻醉药效的影响

目的比较不同剂量布比卡因单用或与普鲁卡因和利多卡因联合应用对臂丛神经阻滞麻醉作用起效与维持时间的影响。方法选用上肢肘部以下手术8068例 ,按一针法穿刺单次给药作腋路臂丛神经阻滞 ,根据使用药物不同 ,随机分为单独布比卡因或布比卡因混合普卡因和利多卡因三类 ,A、B(含肾上腺素0.2mg)两大组 ,每大组按使用布比卡因剂量不同又分为6小组。结果布比卡因混合利多卡因类较单独布比卡因和布比卡因混合普鲁卡因类作用起效时间短 ,维持时间长(P<0.05或P<0.01) ,加用肾上腺素 ,布比卡因不论何种用药剂量均较同种剂量者长(P<0.01) ;布比卡因大剂量与小剂量比较 ,其作用起效时间与维持时间均呈梯度下降。结论所有组方均可安全用于手外科上肢手术的麻醉 ,尤其适用于不同病因、体质、手术时间病人的选用

Effect of bupivacaine combined with procaine orlidocaine on the brachial plexus blockade

Aim The onset of complete blockade of brachial plexus and its sustained time caused by bupivacaine alone or by the drug in combination with procaine and lidocaine were compared. Methods 8086 patients received forearm and hand operations were randomly divided into three groups,namely bupivacaine,bupivacaine plus procaine and bupivacaine plus lidocaine groups. Results The onset time of complete block was shorter and its sustained period was longer in bupivacaine plus lidocaine group than the other groups (P<0.05 or P<0.01).When used with adrenlline,bupivacaine in any dosage would bring a longer sustained period time(P<0.01). With the anesthetic dose decreased,there was a drop in the onset time of complete block and the sustained period. Conclusion All the anesthetic methods could be used in upperlimb's operations in patients who have different pathogenies, physiques and operative times.