微针透皮给药系统应用研究进展

微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。

Progress on micro-needles transdermal drug delivery system

Micro-needles transdermal drug delivery system became the hot spot in the field of transdermal drug delivery system, which had the double advantages in both injection drug delivery and transdermal drug delivery. It also had the merits of fast absorption, continence and painless utility in clinical. Research indicated both transdermal speed and dose of drugs were highly increased when micro-needles transdermal drug delivery system was applied, which especially showed outstanding effects and promise in the preparation of drugs composed of protein, polypeptide, DNA and RNA, etc. Latest developments of micro-needles transdermal drug delivery system were reviewed in this paper. With the development of the industrial arts of the micro-needle, drug delivery technology and application research, micro-needles transdermal drug delivery system would be extensively employed in clinical field.