小牛血去蛋白提取物对大鼠实验性胃溃疡的疗效观察

目的　探讨小牛血去蛋白提取物 (DCBE)对大鼠实验性胃溃疡的治疗作用。方法　乙酸诱导的SD大鼠溃疡模型 ,随机分为 3组。第 1组为对照组 ,生理盐水灌胃 ;第 2、3组DCBE(30、60mg·kg- 1 )灌胃。实验的第 2、4周测量胃酸度、胃蛋白酶活性、溃疡面积、组织白细胞数、髓过氧化物酶(myeloperoxidase,MPO)活性。 结果　DCBE能缩小乙酸诱导大鼠胃溃疡的溃疡面积 ,该作用与降低组织的MPO活性、减少白细胞数等相关 ,但不影响胃酸及胃蛋白酶的活性。结论　DCBE能促进乙酸诱导大鼠胃溃疡的组织愈合

Effect of deproteinised calf blood extract on experimental gastric ulcer in rats

AIM To observe the effect of deprot einised calf blood extract(DCBE) on experimental gastric ulcer in rats. METHODS Ulcer model of SD rats induced by acetic acid, half male and female, were divided into three group s randomly, the control group and the two treatment group DCBE (30 mg·kg -1 or 60 mg·kg -1 ). Following the two and four weeks of experiment, the gastric acid degr ee, activity of pepsin, area of ulcer, the number of tela leukocyte and activity of myeloperoxidase (MPO) were observed. RESULTS Gastric acid deg ree and activity of pepsin showed no significant difference between treatment gr oup and control group, either in DCBE 30 mg·kg -1 or in 60 mg·kg -1 , but area of ulcer, the number of tela leukocyte and the activity of myeloperoxi dase (MPO) showed a significant difference between treatment group and control group and the e ffects of 60 mg·kg -1 group were significantly decreased as compared with that of 30 mg·kg -1 group. CONCLUSION DCBE can significantl y promote tissue healing of gastric ulcer induced by acetic acid in SD rats.