基质金属蛋白酶与膀胱癌分化和浸润的关系

目的 探讨基质金属蛋白酶2（MMP－2）在膀胱移行细胞癌（TCC）中的表达与肿瘤分化和浸润，以及与p53和ki-67表达的关系。方法 采用免疫组化DAKO En Vision System方法，测定MMP－2,p53和ki-67在83例膀胱TCC中的表达。结果 MMP－2在TCC中的性率为63．9％，表达显著高于癌旁粘膜（P＜0．01）；MMP－2表达强度与TCC癌细胞的分化高低和浸润深度呈明显正相关（P＜0．05），并与ki-67表达有显著意义的关联（P＜0．01），但与p53表达无明显相关（P＞0．05）。结论 MMP－2在TCCR的发展和浸润过程中发挥重要作用，可能成为预测TCC预后的参考指标。

Expression of Matrix Metalloproteinase and its Relation to the Differentiation and Invasion in Bladder Transitional Cell Carcinomas

To investigate the expression of MMP 2 in a series of transitional cell carcinoma(TCC) and its relation to the traditional prognostic indicators and the expression of p53 and ki 67. DAKO EnVision System immunohistochemical technique was used to detect the expression of MMP 2, p53 and ki 67 in 83 cases with TCC.MMP 2 immunohistochemical positivity was observed in 63.9% of TCCs and was significantly higher than that in adjacent noncancerous portions(P<0.01). The expression of MMP 2 showed significant relation to the differentiation and invasion of TCC(P<0.05). There was no significant relationship between MMP 2 and p53 expression(P>0.05), but there was highly significant relationship between MMP 2 and ki 67 expression(P<0.01). Conclusion]MMP 2 plays a key role in the development and invasion of TCC. MMP 2 may be a valuable prognostic marker for TCC.