Low-density lipoprotein cholesterol and risk of coronary heart disease among Japanese men and women: the Circulatory Risk in Communities Study (CIRCS) |
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| Authors: | Imano Hironori Noda Hiroyuki Kitamura Akihiko Sato Shinichi Kiyama Masahiko Sankai Tomoko Ohira Tetsuya Nakamura Masakazu Yamagishi Kazumasa Ikeda Ai Shimamoto Takashi Iso Hiroyasu |
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| Affiliation: | a Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japanb Osaka Medical Center for Health Science and Promotion, 1-3-2 Nakamichi, Higashinari-ku, Osaka 537-0025, Japanc Medical Center for Translational Research, Osaka University Hospital, 2-15 Yamadaoka, Suita 565-0871, Japand Division of Health Epidemiology, Chiba Prefectural Institute of Public Health, Nitona government office building, 666-2 Nitonacho, Chuo-ku, Chiba 260-8715, Japane Department of Nursing Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japanf Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japang Department of Society, Human Development and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA |
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| Abstract: | ObjectiveThe objective of this study was to assess the association between serum LDL-cholesterol levels and risk of coronary heart disease (CHD) among Japanese who have lower means of LDL-cholesterol than Western populations.MethodsThe predictive power of estimated serum LDL-cholesterol levels in casual blood samples for risk of CHD was evaluated among residents from four Japanese communities participating in the Circulatory Risk in Communities Study (CIRCS). A total of 8131 men and women, aged 40 to 69 years with no history of stroke or CHD, completed baseline risk factor surveys between 1975 and 1987. By 2003, 155 cases of incident CHD (myocardial infarction, angina pectoris and sudden cardiac death) had been identified.ResultsMean LDL-cholesterol values were 99.4 mg/dL for men and 109.4 mg/dL for women. The crude incidence rate (per 100,000 person-years) of CHD was 152.0 for men and 51.9 for women. The respective multivariable hazard ratios for ≥ 140 mg/dL versus < 80 mg/dL LDL-cholesterol were 2.80 (95% confidence interval: 1.59 to 4.92) for total CHD, 3.83 (1.78-8.23) for myocardial infarction, 4.07 (2.02-8.20) for non-fatal CHD, and 1.24 (0.44-3.47) for fatal CHD.ConclusionSerum LDL-cholesterol levels ranging from around 80 mg/dL to 200 mg/dL were positively associated with risk of CHD in a Japanese population. |
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| Keywords: | Low-density lipoprotein cholesterol Coronary heart disease Myocardial infarction Incidence Cohort study Population-based study |
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