Population attributable numbers and fractions of deaths due to smoking: a pooled analysis of 180,000 Japanese |
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Authors: | Murakami Yoshitaka,Miura Katsuyuki,Okamura Tomonori,Ueshima Hirotsugu EPOCH-JAPAN Research Group |
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Affiliation: | a Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japanb Department of Health Science, Shiga University of Medical Science, Otsu, Japanc Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japand Life-related Disease Prevention Center, Shiga University of Medical Science, Otsu, Japan |
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Abstract: | ObjectiveAge- and sex-specific population attributable fraction (PAF) and premature deaths attributable to smoking were estimated from a pooled analysis of cohort studies in Japan.MethodsA pooled analysis of individual participant data from 13 well-qualified cohort studies throughout Japan (a total of 183,251 Japanese aged 40-89, 69,502 men and 113,749 women; the baseline years between 1987 and 1995 with average 10 years of follow-up) was performed. Poison regression model was used to estimate age- and sex-specific hazard ratios, and their PAFs of all-cause deaths and number of annual premature deaths attributable to smoking were estimated.ResultsOverall PAF attributable to smoking was 24.6% in men and 6.0% in women. The estimated number of annual premature deaths due to smoking was 121,854 (men: 109,998; women: 11,856) in Japan. The age-specific PAF was largest in men aged 60-69 (47.7%) and in women aged 50-59 (12.2%). In the older group aged 70-79 and 80-89, PAF was 15.4% and 8.0% in men and 3.5% and 1.5% in women, respectively.ConclusionsAge-specific PAFs attributable to smoking in Japanese men are much larger than that reported from other Asian countries. |
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Keywords: | Pooled analysis Total mortality Smoking Population attributable fraction |
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