人参茎叶总皂甙对原发性免疫缺陷大鼠(SHR)的免疫调节作用

应用空斑形成试验,花结形成试验及ConA诱导脾细胞增殖试验等测定了人参茎叶总皂甙对SHR大鼠的免疫调节作用。结果人参总皂甙在体内能使SHR大鼠脾细胞空斑形成值显著增加,对胸腺细胞的花环形成值有微弱作用,在体外对conA诱导的脾细胞增殖反应有明显促进作用,提示人参茎叶总皂甙在体内对萎缩性胸腺所致的细胞免疫功能缺陷作用甚微,但能激活脾脏内T细胞增殖,从而调节SHR大鼠的体液免疫功能。本文是在“人参茎叶总皂甙对自发性高血压大鼠免疫功能和高血压的影响一文的基础上,又增添了人参茎叶总皂甙不同给药途径对SHR大鼠免疫功能影响的观察。人参茎叶总皂甙对SHR大鼠免疫调节的给药途径以灌服最佳,皮下注射次之,腹腔注射较差。给药最适浓度为150mg/kg/日。

Effects of GS on immune regulation of SHR

The effects of Ginsenoside(GS) on immunological regulation of the spontaneous hypertensive rats(SHR) were measured by plaque-forming test rossett forming test and spleen cell proliferation test induced by Con A. The results showed that GS could significantly raise the number of spleen plaque-forming cells of SHR in vivo, had little influence on the number of thymus cell forming rossett and significantly improved spleen cell proliferation action induced by Con A outside the body of SHR and that GS had slight effect on cellular immunodeficiency caused by atrophied thymnus, but GS could activate Tlymphocytes in the spleen and cause them to proliferate so that it could regulate the function of humoral immunity. GS is better administered by mouth, than by hypodermic injection. The result of intraperitoneal injection is unsatisfactory. The proper concentration of administration is 150 mg per kelogram a day (150 mg/kg/day).