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| 嗅鞘细胞静脉移植治疗脊髓损伤(英文) | |
| 引用本文： | 魏开斌,刘雨亮,刘红,吕昕刚,张文正,李军. 嗅鞘细胞静脉移植治疗脊髓损伤(英文)[J]. 中国组织工程研究与临床康复, 2011, 15(27): 5021-5025. DOI: 10.3969/j.issn.1673-8225.2011.27.018 |
| 作者姓名： | 魏开斌 刘雨亮 刘红 吕昕刚 张文正 李军 |
| 作者单位： | 1. 泰安市中心医院骨科诊疗部,山东省泰安市,271000 2. 泰安市中心医院护理部,山东省泰安市,271000 3. 新汶矿务局莱芜中心医院,山东省莱芜市,271100 |
| 基金项目： | No.2007BS03035，山东省优秀中青年科学家科研奖励基金资助项目 |
| 摘 要： | 背景:嗅鞘细胞移植治疗脊髓损伤在众多疗法中效果较佳,成为最有前景的治疗方法之一。目前移植方法为局部移植,存在操作复杂、创伤大、重复移植治疗困难等缺点。寻找一种简单易行且疗效好的移植方法成为各国学者研究的热点。目的:分析嗅鞘细胞静脉移植治疗脊髓损伤的可行性和疗效。方法:制备Wistar大鼠脊髓半切模型,随机分4组:嗅鞘细胞髓内局部移植组、嗅鞘细胞静脉移植组、D/F12静脉移植组和空白对照组。定期行CBS功能评分及组织学检查,评价脊髓修复情况。结果与结论:嗅鞘细胞髓内局部移植组、嗅鞘细胞静脉移植组的功能恢复和组织学改变优于D/F12静脉移植组和空白对照组,嗅鞘细胞髓内局部移植组、嗅鞘细胞静脉移植组间无显著差别。说明嗅鞘细胞静脉移植可向脊髓损伤部位迁移并修复脊髓损伤,其疗效与嗅鞘细胞髓内局部移植相当。 |
| 关 键 词： | 嗅鞘细胞 髓内局部移植 脊髓损伤 静脉移植 疗效 |
Vein transplantation of olfactory ensheathing cells for spinal cord injury |
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| Wei Kai-bin,Liu Yu-liang,Liu Hong,Lü Xin-gang,Zhang Wen-zheng,Li Jun. Vein transplantation of olfactory ensheathing cells for spinal cord injury[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(27): 5021-5025. DOI: 10.3969/j.issn.1673-8225.2011.27.018 | |
| Authors: | Wei Kai-bin Liu Yu-liang Liu Hong Lü Xin-gang Zhang Wen-zheng Li Jun |
| Affiliation: | Wei Kai-bin1,Liu Yu-liang1,Liu Hong2,Lü Xin-gang3,Zhang Wen-zheng1,Li Jun1 1Department of Orthopedics,2Department of Nuring,Taian City Central Hospital,Taian 271000,Shandong Province,China,Laiwu Central Hospital of Xinwen Mining Bureau,Laiwu 271100 |
| Abstract: | BACKGROUND:Olfactory ensheathing cell transplantation is a better theray for spinal cord injury,and it becomes one of the most promising treatment methods.Local transplantation is applied currently,with the disadvantages of complex operation,large trauma,repeated transplantation.Looking for a simple and effective way for cell transplantation becomes a hotspot for scholars from various countries.OBJECTIVE:To investigate the effect and possibility of transplantation of olfactory ensheathing cells for treatmen... |
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