| 生肌玉红胶原海绵修复创面损伤 |
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| 引用本文： | 严婷婷,熊猛,周勇,姚昶. 生肌玉红胶原海绵修复创面损伤[J]. 中国组织工程研究与临床康复, 2011, 15(29): 5367-5370. DOI: 10.3969/j.issn.1673-8225.2011.29.012 |
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| 作者姓名： | 严婷婷 熊猛 周勇 姚昶 |
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| 作者单位： | 1. 东南大学附属中大医院整形外科,江苏省南京市,210009
2. 江苏省中医院普外科,江苏省南京市,210009 |
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| 基金项目： | 国家自然科学基金项目，江苏省中医药领军人才项目 |
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| 摘 要： | 背景:生肌玉红胶原海绵能显著促进创面愈合。目的:观察生肌玉红胶原海绵对兔皮肤创面愈合的影响。方法:在新西兰白兔背部制造3处全层皮肤缺损创面,分别以生肌玉红胶原海绵、贝复剂(重组碱性成纤维细胞生长因子外用溶液)、生理盐水修复。观察各组创面愈合时间、创面愈合率,检测创面修复组织内成纤维细胞数、血红素氧化酶1、转化生长因子β1 mRNA与蛋白及增殖细胞核抗原蛋白表达。结果与结论:与贝复剂、生理盐水比较,生肌玉红胶原海绵可显著促进成纤维细胞增殖(P<0.05),增加创面血红素氧化酶1、转化生子因子β1及增殖细胞核抗原的表达(P<0.05),提高创面愈合率(P<0.05),缩短创面愈合时间(P<0.05)。证实生肌玉红胶原海绵能够促进创面修复,其作用机制可能是通过提高创面血红素氧化酶1、转化生长因子β1表达促进细胞增殖,增加成纤维细胞等创面修复细胞。
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| 关 键 词： | 生肌玉红胶原海绵 创面愈合 血红素氧化酶1 转化生长因子β1 增殖细胞核抗原 |
Sheng Ji Yu Hong collagen matrices for repair of skin wound |
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| Yan Ting-ting,Xiong Meng,Zhou Yong,Yao Chang. Sheng Ji Yu Hong collagen matrices for repair of skin wound[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(29): 5367-5370. DOI: 10.3969/j.issn.1673-8225.2011.29.012 |
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| Authors: | Yan Ting-ting Xiong Meng Zhou Yong Yao Chang |
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| Affiliation: | Yan Ting-ting1,Xiong Meng2,Zhou Yong2,Yao Chang2 1Department of Plastic Surgery,Zhongda Hospital,Southeast University,Nanjing 210009,Jiangsu Province,China,2Department of General Surgery,Jiangsu Hospital of Traditional Chinese Medicine |
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| Abstract: | BACKGROUND: Sheng Ji Yu Hong collagen matrices can obviously promote wound healing. OBJECTIVE: To observe the effect of Sheng Ji Yu Hong collagen matrices on rabbit skin wound healing. METHODS: Three full-thickness skin wounds were made and repaired with Sheng Ji Yu Hong collagen matrices, BFGF agent, normal saline solution, separately. Healing time, healing ratio, number of fibroblasts, hemeoxygenase-1 level, transforming growth factor β1 mRNA and protein expression, and proliferating cell nuclear antigen expression were observed. RESULTS AND CONCLUSION: Sheng Ji Yu Hong could promote the proliferation of fibroblasts more remarkably than BFGF agent and normal saline (P < 0.05), increase expressions of hemeoxygenase-1 level, transforming growth factor β1 and proliferating cell nuclear antigen (P < 0.05), elevate healing rate (P < 0.05), and shorten healing time (P < 0.05). Sheng Ji Yu Hong collagen matrices can promote skin wound healing obviously, and the mechanism maybe relates to elevate the expression of hemeoxygenase-1 level and transforming growth factor β1, and preserve the activity of prosthetic cells . |
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