血浆血栓素A2/前列腺素I2值与骨骼肌无复流现象

背景:在骨骼肌无复流现象中血栓素A2及前列腺素I2是重要参与因子.目的:观察下肢动脉栓塞患者血浆血栓素A2/前列腺素I2值与骨骼肌发生无复流现象的关系.方法:选择经影像学及临床表现确诊为下肢动脉栓塞患者36例,行下肢动脉取栓,根据患者取栓后缺血肢体是否发生无复流现象分为无复流组(n=10)和对照组(n=26).结果与结论:与对照组比较,无复流组取栓后0 h无复流组前列腺素I2明显减少(P < 0.01);取栓后24 h,无复流组血栓素A2明显升高、前列腺素I2明显下降(P < 0.01).与对照组相比,无复流组术后血栓素A2/前列腺素I2值升高(P < 0.05).与术前相比,对照组术后血栓素A2/前列腺素I2值升高后然后下降,无复流组取栓后均维持较高的水平.而取栓前后两组血小板数量及血浆纤维蛋白原的水平差异均无显著性意义.同时术后24 h点无复流组血栓素A2/前列腺素I2值与纤维蛋白原呈正相关(r=0.613,P=0.049);而与血小板数量无相关性(r=0.199,P=0.543).提示血栓素A2/前列腺素I2值可以作为判断动脉栓塞患者缺血再灌注后骨骼肌发生无复流现象的指标之一.

Relationship between plasma thromboxane A2/prostaglandin I2 value and no-reflow phenomenon in acute limb arterial embolism patients

BACKGROUND:Microcirculation disturbance plays an important role in the no-reflow phenomenon in skeletal muscle, thromboxane A2 (TXA2) and prostaglandin I2 (PGI2) are the important factors to ensure microcirculation balance. OBJECTIVE:To investigate the relationships between plasma TXA2/PGI2 value and the no-reflow phenomenon in skeletal muscle. METHODS: Thirty-six patients with lower extremity arterial thrombosis confirmed by imaging results and clinical manifestations were included in this study. After emb...