| 外周血间充质干细胞移植心肌梗死兔新生血管及心功能的变化 |
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| 引用本文： | 刘志江,石蓓,赵然尊,沈长银,王冬梅,王正龙.外周血间充质干细胞移植心肌梗死兔新生血管及心功能的变化[J].中国组织工程研究与临床康复,2011,15(27):5039-5043. |
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| 作者姓名： | 刘志江 石蓓 赵然尊 沈长银 王冬梅 王正龙 |
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| 作者单位： | 遵义医学院第一附属医院心内科,贵州省遵义市,563003 |
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| 摘 要： | 背景:药物治疗和支架置入治疗尚不能修复心肌梗死后已坏死的心肌。目的:观察外周血间充质干细胞移植治疗对心肌梗死兔新生血管及心功能的影响。方法:随机抽签法将36只大白兔分为假手术组,间充质干细胞移植组和对照组,结扎兔冠状动脉左室支建立心肌梗死模型。结果与结论:移植后4周,流式细胞仪分析显示绝大部分间充质干细胞表达CD44,极少量细胞表达CD34和CD45。间充质干细胞移植组梗死心肌组织有移植的间充质干细胞存活,超声心动仪示间充质干细胞移植组左心室射血分数及短轴缩短率明显高于对照组(P<0.01);左心室收缩末内径和舒张末内径明显小于对照组(P<0.01)。间充质干细胞移植组心肌纤维化程度、心肌梗死面积均明显小于对照组(P<0.01)。免疫组织化学染色显示间充质干细胞移植组新生毛细血管密度明显高于对照组(P<0.01)。提示外周血间充质干细胞移植增加了梗死心肌新生血管密度,改善心脏的功能。
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| 关 键 词： | 间充质干细胞 心肌梗死 外周血 细胞移植 兔 |
Effect of peripheral blood mesenchymal stem cells transplantation on neovascularization and cardiac function of myocardial infarction rabbits |
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| Liu Zhi-jiang,Shi Bei,Zhao Ran-zun,Shen Chang-ying,Wang Dong-mei,Wang Zheng-long.Effect of peripheral blood mesenchymal stem cells transplantation on neovascularization and cardiac function of myocardial infarction rabbits[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(27):5039-5043. |
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| Authors: | Liu Zhi-jiang Shi Bei Zhao Ran-zun Shen Chang-ying Wang Dong-mei Wang Zheng-long |
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| Institution: | Liu Zhi-jiang,Shi Bei,Zhao Ran-zun,Shen Chang-ying,Wang Dong-mei,Wang Zheng-long Department of Cardiology,the First Affiliated Hospital of Zunyi Medical College,Zunyi 563003,Guizhou Province,China |
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| Abstract: | BACKGROUND:Both Drug treatment and percutaneous coronary intervention cannot repair the necrotic myocardium following myocardial infarction.OBJECTIVE:To investigate the effect of peripheral blood mesenchymal stem cells(MSCs) transplantation on the neovascularization and cardiac function following myocardial infarction in rabbits.METHODS:Thirty-six New Zealand rabbits were divided into MSCs transplantation group(n=12),control group(n=12) and sham operation group(n=12).Rabbits models of acute myocardial infar... |
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