| 18FDG-PET术前评估骨与软组织肿瘤治疗效果的Meta分析 |
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| 引用本文： | 姬涛,朱赛楠,郭卫,汤小东,唐顺. 18FDG-PET术前评估骨与软组织肿瘤治疗效果的Meta分析[J]. 中国组织工程研究与临床康复, 2011, 15(30): 5569-5572. DOI: 10.3969/j.issn.1673-8225.2011.30.015 |
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| 作者姓名： | 姬涛 朱赛楠 郭卫 汤小东 唐顺 |
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| 作者单位： | 1. 北京大学人民医院骨与软组织肿瘤治疗中心,北京市,100044
2. 北京大学第一医院医学统计室,北京市,100034 |
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| 摘 要： | 背景:18FDG-PET可为骨和软组织肿瘤的良恶性鉴别,病变定位,恶性程度评价,活检部位的确定,治疗效果评估和判断预后提供重要信息。目的:采用Meta分析方法评价18FDG-PET在术前骨与软组织肿瘤治疗疗效评估方面的应用价值。方法:检索PubMed、EMBASE、Cochrance、CNKI、万方数据库及维普中文科技期刊数据库获得PET用于骨与软组织肿瘤诊治方面的临床研究。结果与结论:对符合纳入标准的9项临床非随机对照研究进行Meta分析,文献质量评价循证医学推荐级别3项研究为B级,6项为C级,检验提示无发表偏倚。将治疗前后最大标准摄取值SUV2/SUV1≤0.5作为预测术后肿瘤坏死率≥90%的敏感性和特异性分别为0.82(95%CI,0.72～0.89)和0.61(95%CI,0.49～0.71)。SROC为6.17(95%CI,2.84～13.39)。说明将化疗前后最大标准摄取值比值作为评价术前疗效的敏感性较好,但缺乏特异性;应综合18FDG-PET检查结果与其他辅助检查结果对术前疗效进行综合评估。
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| 关 键 词： | 软组织肉瘤 骨肿瘤 FDG-PET 诊断价值 Meta分析 |
Meta analysis of 18F-deoxyglucose-positron emission tomography value in evaluation of response to therapy for primary bone and soft tissue sarcomas |
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| Ji Tao,Zhu Sai-nan,Guo Wei,Tang Xiao-dong,Tang Shun. Meta analysis of 18F-deoxyglucose-positron emission tomography value in evaluation of response to therapy for primary bone and soft tissue sarcomas[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(30): 5569-5572. DOI: 10.3969/j.issn.1673-8225.2011.30.015 |
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| Authors: | Ji Tao Zhu Sai-nan Guo Wei Tang Xiao-dong Tang Shun |
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| Affiliation: | Ji Tao1,Zhu Sai-nan2,Guo Wei1,Tang Xiao-dong1,Tang Shun1 1Musculoskeletal Tumor Center,People's Hospital,Peking University,Beijing 100044,China,Department of Statistics,Peking University First Hospital,Beijing 100034 |
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| Abstract: | BACKGROUND:18 F-deoxyglucose-positron emission tomography(18FDG-PET) can be used for bone and soft tissue malignant tumor identification,lesion location,degree of malignancy evaluation,biopsy site identification,effect and prognostic assessment.OBJECTIVE:To assess the value of 18FDG-PET in the evaluation of preoperative therapy response of bone and soft tissue sarcomas by systematic review and meta-analysis.METHODS:Databases of PubMed,Embase,Cochrane,CNKI,WanFang and VIP databases were searched for articles... |
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