创伤及急性炎症患者血清肿瘤相关物质的变化及其临床意义

研究机械性创伤及急性感染性炎症患者血清肿瘤相关物质（TSGF）的变化，探讨其原因及临床意义。以40例正常成年人作正常对照组，测定了60例机械性创伤患者（39例轻度，21例重度）及37例急性感染性炎症患者于创伤或感染后第1、3和12天时的血清TSGF的含量。结果显示，创伤或感染后第1天和第3天，患者血清TSGF的含量均明显高于正常对照组（P＜0．05，P＜0．01），第12天时重度创伤及急性炎症患者血清TSGF的含量仍明显高于正常对照组（P＜0．01），而轻度创伤患者与正常对照组比较差异无显著性意义（P＞0．05）。提示TSGF与创伤修复和炎症反应有关。

SERUM LEVEL CHANGE OF TUMOR RELALED FACTORS IN PATIENTS WITH MECHANICAL TRAUMA AND ACUTE INFLAMMATION AND ITS CLINICAL SIGNIFICANCE

To investigate the serum level changes of tumor related factors in patients with mechanical trauma and with acute inflammation, and to inquire into the possible reason and its clinical significance, TSGF level was detected on day 1, 3 and 12 after trauma or inflammation in 60 patients with mechanical trauma (39 with mild trauma and 21 with severe trauma) and 37 patients with acute inflammation, while 40 healthy persons were selected as the normal control group. TSGF serum level was significantly higher in patients with trauma and with infectious inflammation than that in normal control group on day 1 and day 3( P <0 05, P <0 01). On day 12, TSGF serum level in patients with severe trauma was significantly higher than that in normal control group ( P <0 01), but had no marked difference between patients with mild trauma and healthy persons ( P >0 05).The results suggest that TSGF is related with the recovery of trauma and inflammatory response.