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急性心肌梗塞病人血清CK-MM亚型的检测
引用本文:田建会,许绍辉,田玉聚. 急性心肌梗塞病人血清CK-MM亚型的检测[J]. 青岛大学医学院学报, 1997, 0(2)
作者姓名:田建会  许绍辉  田玉聚
作者单位:青岛医学院附属医院心内科,上海长征医院实验科
摘    要:①目的观察急性心肌梗塞(AMI)病人血清肌酸磷酸激酶(CK)及其亚型的变化,以探讨对AMI早期诊断及病情变化的意义。②方法应用琼脂糖凝胶电泳法检测20例AMI病人血清CK总活力及其亚型MM变化,并与对照组和心绞痛组进行了比较。③结果AMI发病3h内,CK总活力和CK-MB与对照组和心绞痛组均无明显改变,而MM3及MM3/MM1比值则明显高于上述两组(t=7.81,10.08,P均<0.01)。AMI发病后,CK总活力和CK-MB达到峰值时间分别为23.2和21.6h,而MM3/MM1则在12.3h达到峰值,MM3/MM1比值达峰值时间明显缩短(t=7.45,P<0.01)。④结论检测CK及其亚型的变化有助于对AMI的早期诊断和病情判断。

关 键 词:肌酸激酶同功酶类;心肌梗塞;诊断;心血管

DETECTION OF SERUM CK MM ISOFORMS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Tian Jianhui,Xu Shaohui,Tian Yuju. DETECTION OF SERUM CK MM ISOFORMS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION[J]. Acta Academiae Medicinae Qingdao Universitatis, 1997, 0(2)
Authors:Tian Jianhui  Xu Shaohui  Tian Yuju
Affiliation:Tian Jianhui,Xu Shaohui,Tian Yuju Department of Cardiology,The Affiliated Hospital of Qingdao Medical College,Qingdao 266003
Abstract:Objective To observe the changes of serum creatine kinase isoforms after the onset of acute myocardial infartion(AMI) . Methods Changes of serum total CK and CK isoforms from 20 patients with acute myocardial infarction were detected with agrose gel electrophoresis method and compared with normal subjects and patients with angina pectoris respectively. Results Within 3 hours after heart attack, the serum total CK and CK Mb showed no significant difference compared with that of AMI patients, normal subjects and angina pectoris patients. But MM 3 and MM 3/MM 1 were significantly higher than that of the two control groups( t=7.81, 10.08; P <0.01). Total CK and CK Mb of AMI patients reached the peak value at 23.2 and 21.6 h, while MM 3/MM 1 reached the peak value at 12.3h. The time difference was significant( t=7.45, P<0.01). Conclusion Detection of CK MM isoforms is helpful for diagnosis of AMI and for assessing the conditions of patients.
Keywords:creatine kinase  myocardium infarction  diagnosis  cardiovascular
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