| 脆性组氨酸三聚体基因及错配修复基因 hMLH1在口腔鳞状细胞癌中的表达及意义 |
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| 引用本文： | 谷建琦,张英怀,杨威,张杰英,蒋崇槟,贾志宇. 脆性组氨酸三聚体基因及错配修复基因 hMLH1在口腔鳞状细胞癌中的表达及意义[J]. 第三军医大学学报, 2007, 29(2): 151-153 |
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| 作者姓名： | 谷建琦 张英怀 杨威 张杰英 蒋崇槟 贾志宇 |
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| 作者单位： | 河北省人民医院口腔科;河北医科大学第二附属医院口腔科,石家庄,050017 |
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| 摘 要： | 目的 探讨脆性组氨酸三聚体基因(fragile histidine triad,FHIT)和hMLH1基因在口腔鳞状细胞癌组织中的表达及其相互关系.方法 采用免疫组化法检测69例口腔鳞状细胞癌和40例正常口腔黏膜组织中FHIT和hMLH1的表达情况.资料的统计学处理用SPSS软件完成,比较用x2检验.结果 口腔鳞状细胞癌组织中FHIT、hMLH1的阳性表达率(46.4%,47.8%)低于正常口腔黏膜组织(77.5%,77.5%),有显著性差异(P＜0.05).结论 FHIT和hMLH1可能在口腔鳞状细胞癌的发生发展中发挥重要作用.
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| 关 键 词： | 口腔鳞状细胞癌 脆性组氨酸三聚体 错配修复基因hMLH1 免疫组织化学 |
| 文章编号： | 1000-5404（2007）02-0151-03 |
| 修稿时间： | 2006-03-27 |
Expression of fragile histidine triad gene and mismatch repair gene hMLH1 in oral squamous cell carcinoma |
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| GU Jian-qi,ZHANG Ying-huai,YANG Wei,ZHANG Jie-ying,JIANG Chong-bin,JIA Zhi-yu. Expression of fragile histidine triad gene and mismatch repair gene hMLH1 in oral squamous cell carcinoma[J]. Acta Academiae Medicinae Militaris Tertiae, 2007, 29(2): 151-153 |
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| Authors: | GU Jian-qi ZHANG Ying-huai YANG Wei ZHANG Jie-ying JIANG Chong-bin JIA Zhi-yu |
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| Abstract: | Objective To study the expressions of fragile histidine triad (FHIT) and hMLH_1 in oral squamous cell carcinoma (OSCC) and their correlativity. Methods Immunohistochemistry was used to detect the expressions of FHIT and hMLH_1 in 69 OSCC and 40 normal oral mucosa. The data was analyzed by Chi-square test. Results The positive rate of FHIT and hMLH_1 in OSCC (46.4% and 47.8%) was lower than that in normal oral mucosa (77.5% and 77.5%), with statistically significant difference (P<0.05). The correlation between FHIT and hMLH_1 was statistically significant (P<0.05). Conclusion FHIT and hMLH_1 may play an important role in the occurrence and development of OSCC. |
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| Keywords: | oral squamous cell carcinoma fragile histidine triad mismatch repair gene hMLH_1 immunohistochemistry |
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