Optimization of a formulation for direct compression using a simplex lattice design |
| |
Authors: | Herman V. van Kamp Gerad K. Bolhuis Coenraad F. Lerk |
| |
Affiliation: | (1) Laboratory for Pharmaceutical Technology and Dispensing, State University of Groningen, Ant. Deusinglaan 2, 9713 AW Groningen, the Netherlands;(2) Present address: Organon International BV, P.O. Box 20, 5340 BH Oss, the Netherlands |
| |
Abstract: | In this paper it is demonstrated how the optimum composition of a mixture for direct compression consisting of -lactose monohydrate, roller-dried -lactose and microcrystalline cellulose can be found using a systematic optimization technique. The experiments were chosen according to a simplex lattice design. The results of these experiments were used to fit a mathematical model, which then can predict the properties of all possible mixture compositions and enables a graphic representation of these properties in the form of contour plots. At a level of 4% the effect of three disintegrants (sodium starch glycolate, croscarmellose sodium and crospovidone) on the properties of the tablets compressed from these filler-binders, was evaluated by superimposing the contour plots of the different tablet responses. It was found that all the disintegrants used were effective in this combination of filler-binders. In order to evaluate drug dissolution rate an extra experiment with crospovidone as the disintegrant was performed, in which oxazepam was used as a test drug. |
| |
Keywords: | Cellulose Compaction Crushing strength Disintegration time Friability Lactose Optimization Tablets |
本文献已被 SpringerLink 等数据库收录! |
|