糖化血红蛋白对糖尿病诊断及监测的临床意义

目的　探讨糖化血红蛋白 (HBAIC)在糖尿病诊断及监测中的意义。方法　在HITACHZ 71 70全自动生化分析仪上测定HBAIC及血糖 (GLU)含量。其中 ,正常对照组 42例 ,非糖尿病性血糖升高组 2 2例 ,2型糖尿病 (NIDDM)组 5 7例。结果　NIDDM组血糖及HBAIC明显高于正常对照组 ,非糖尿病性血糖升高组GLU明显高于正常对照组 (P <0 .0 1 ) ,而HBAIC无明显差异 (P >0 .0 1 )。GLU水平越高HBAIC含量越高 (P <0 .0 1 )。糖尿病并发症的发生率随HBAIC水平升高而升高 (P <0 .0 1 )。结论　HBAIC是监测糖尿病发生发展转归的良好指标 ,对非糖尿病性血糖升高的鉴别诊断也有一定意义。

The Clinical Significance of Glycosylated Hemoglobin Test in the Diagnosis and Surveillance of Diabetes

Objective To discuss the significance of glycosylated hemoglobin (HbA1c) test in the diagnosis and surveillance of diabetes. Methods Levels of HBAIC and glucose in blood were determined with automatic biochemical analyzer among 3 groups, i.e. the 1st group containing 57 patients with type II diabetes or non insulin dependent diabetes mellitus (NIDDM), the 2nd group containing 22 ones with postoperative non diabetes high blood glucose after fracture, and the 3rd group containing 42 normal controls. Results The levels of HBAIC and glucose of the 1st group were significantly higher than that of the 3rd group consisting of normal controls ( P <0.01). The level of glucose of the 2nd group was higher than that of the 3rd group ( P <0.01), while there was no clear difference in the level of HBAIC between them. In the 3rd group, the higher the glucose level, the higher the HBAIC level ( P <0.01). The incidence of complication of diabetes increased when the level of HBAIC was high.Conclusion HBAIC, as a test parameter, is significant in the surveillance of development of diabetes, and in the differential diagnosis of non-diabetes high blood glucose, too.