不同化疗方案治疗晚期大肠癌的疗效观察

目的：研究奥沙利铂、氟尿嘧啶和亚叶酸钙（FOLFOX方案）联合治疗晚期大肠癌的疗效和毒性反应，并将该方案与氟尿嘧啶、亚叶酸钙（DeGramont方案）治疗方案相比较。方法：经病理确诊的晚期大肠癌62例分为两组，治疗组32例，予以FOLFOX方案治疗；对照组30例，予以DeGramont方案治疗。两组均治疗4个化疗周期以上。结果：治疗组有效率为46．9％，常见的毒性反应为神经毒性；对照组有效率为16．7％，与治疗组差别有统计学意义，未见神经毒性，其他毒性反应与治疗组无统计学差异。结论：奥沙利铂联合氟尿嘧啶和亚叶酸钙治疗晚期大肠癌，患者对其耐受良好，毒副反应较轻，疗效高于氟尿嘧啶加亚叶酸钙方案。

The evaluation of efficacy of different combined chemotherapy regimen for advanced colorectal carcinoma.

Objective： To study the efficacy and toxicity of oxaliplatin, 5 Fu and CF for advanced colorectal carcinoma. Methods： 62 colorecta carcinoma patients were randomized into FOLFOX4 group（n = 32）and regimen（n = 30）. All patients received four course of chemotherapy. The treatments were both repeated every 2 weeks. Results：The overall reponae rate of the group with oxaliplatin was 46.9%0（15/32）. The main toxicity was neurotoxicity. And the overall response rate of the group without oxalip-latin was 16.7% （5/30）. Conclusions： Our results indicated that combined oxaliplatin and 5-Fu with CF regimen was effective for advanced eolorectal cancer. And this regimens was superior to that without oxaliplatin.