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不同化疗方案治疗晚期大肠癌的疗效观察
引用本文:盛妙华.不同化疗方案治疗晚期大肠癌的疗效观察[J].中国冶金工业医学杂志,2010,27(1):22-23.
作者姓名:盛妙华
作者单位:湖南湘潭钢铁公司职工医院,湖南湘潭,411101
摘    要:目的:研究奥沙利铂、氟尿嘧啶和亚叶酸钙(FOLFOX方案)联合治疗晚期大肠癌的疗效和毒性反应,并将该方案与氟尿嘧啶、亚叶酸钙(DeGramont方案)治疗方案相比较。方法:经病理确诊的晚期大肠癌62例分为两组,治疗组32例,予以FOLFOX方案治疗;对照组30例,予以DeGramont方案治疗。两组均治疗4个化疗周期以上。结果:治疗组有效率为46.9%,常见的毒性反应为神经毒性;对照组有效率为16.7%,与治疗组差别有统计学意义,未见神经毒性,其他毒性反应与治疗组无统计学差异。结论:奥沙利铂联合氟尿嘧啶和亚叶酸钙治疗晚期大肠癌,患者对其耐受良好,毒副反应较轻,疗效高于氟尿嘧啶加亚叶酸钙方案。

关 键 词:奥沙利铂  氟尿嘧啶  亚叶酸钙  大肠癌  联合化疗

The evaluation of efficacy of different combined chemotherapy regimen for advanced colorectal carcinoma.
SHENG Miao-hua.The evaluation of efficacy of different combined chemotherapy regimen for advanced colorectal carcinoma.[J].Chinese Medical Journal of Metallurgical Industry,2010,27(1):22-23.
Authors:SHENG Miao-hua
Institution:S HENG Miao-hua. (Dpartment of Oncology Workers'Hospital, Xiangtan Iron and Steel Company, Xiangtan 411101 )
Abstract:Objective: To study the efficacy and toxicity of oxaliplatin, 5 Fu and CF for advanced colorectal carcinoma. Methods: 62 colorecta carcinoma patients were randomized into FOLFOX4 group(n = 32)and regimen(n = 30). All patients received four course of chemotherapy. The treatments were both repeated every 2 weeks. Results:The overall reponae rate of the group with oxaliplatin was 46.9%0(15/32). The main toxicity was neurotoxicity. And the overall response rate of the group without oxalip-latin was 16.7% (5/30). Conclusions: Our results indicated that combined oxaliplatin and 5-Fu with CF regimen was effective for advanced eolorectal cancer. And this regimens was superior to that without oxaliplatin.
Keywords:Oxaliplatin  5-FU  CF  Colorectal Cancer  Combined chemotherapy
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